Ethyl 1-(3,4-dichlorobenzyl)-4-nitro-1H-indole-2-carboxylate CAS 220677-29-2
| CAS No. | 220677-29-2 |
| Molecular Formula | C18H14Cl2N2O4 |
| Molecular Weight | 393.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 1-(3,4-dichlorobenzyl)-4-nitro-1H-indole-2-carboxylate.
CATO supplies Ethyl 1-(3,4-dichlorobenzyl)-4-nitro-1H-indole-2-carboxylate (CAS 220677-29-2), a certified reference material (molecular formula C18H14Cl2N2O4, MW 393.22 g/mol) for analytical method development and quality control.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Ethyl 1-(3,4-dichlorobenzyl)-4-nitro-1H-indole-2-carboxylate is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 393.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H14Cl2N2O4 |
| Molecular Weight | 393.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ethyl Standards
- 2-[(2,4-dichlorobenzyl)oxy]-1,3-dioxo-1,2,3,4-tetrahydro-4-isoquinolinecarbaldehyde O-methyloxime (CAS 338419-50-4)
- 1-(3-((2,4-Dichlorobenzyl)oxy)thiophen-2-yl)-3-phenylurea (CAS 339009-61-9)
- 4-((3,4-Dichlorobenzyl)thio)-5-methoxy-2-phenylpyridazin-3(2H)-one (CAS 5509-75-1)
- N-(2,4-Dichlorobenzyl)-2-((4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 869714-38-5)
- N-(2,4-Dichlorobenzyl)-2,2,2-trifluoro-N-(3-nitrophenyl)acetamide (CAS 313233-78-2)
- 2-((2,4-Dichlorobenzyl)thio)-3-isobutylquinazolin-4(3H)-one (CAS 329779-74-0)
- 3-(2,4-Dichlorobenzyl)-4-hydroxy-1-(3-(methylthio)phenyl)pyridin-2(1H)-one (CAS 672949-08-5)
- 3-((2,6-Dichlorobenzyl)oxy)-1-(4-fluorobenzyl)-2-methylpyridin-4(1H)-one (CAS 338965-40-5)
Recommended Standards
- 3-Iodo-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)benzamide (CAS 914397-50-5)
- N-(2-((3,4-Dichlorophenyl)amino)-2-oxoethyl)-N-(furan-2-ylmethyl)furan-2-carboxamide (CAS 332848-64-3)
- Anagrelide Impurity 31 (CAS CATO-C4X-224031)
- 1-(2-Iodophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline (CAS 143600-70-8)
- 1-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one (CAS 16223-25-9)
- 2-Methyl-6-nitrobenzenesulfonyl Chloride (CAS 56202-22-3)
- Quinoline-7-carbonitrile (CAS 67360-38-7)
- Ethyl 2-amino-2-(2-chlorophenyl)acetate (CAS 500772-75-8)
- 1-(7-Bromo-1H-indol-3-yl)-2-chloroethan-1-one (CAS 1018593-32-2)
- 3-((3-Chloro-4-hydroxyphenyl)amino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione (CAS 264218-23-7)
- 1-(1H-indol-3-yl)-3-methylbutan-1-one (CAS 69622-34-0)
- 3-Fluoro-1-oxa-7-azaspiro[4.5]Decane (CAS 2168335-03-1)
- 1-(Tetrahydro-2-furanylmethyl)-1h-benzimidazole-5-carboxylic acid (CAS 943113-44-8)
- Xenopsin-Related Peptide 2 (XP-2) (H-9340.0005) (CAS 117442-29-2)
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