Macitentan Impurity 17 CAS 2211054-90-7
| CAS No. | 2211054-90-7 |
| Molecular Formula | C10H8Br2N4O2 |
| Molecular Weight | 376.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Macitentan Impurity 17 (CAS 2211054-90-7, C10H8Br2N4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Macitentan Impurity 17 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 376.00 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Macitentan Impurity 17 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H8Br2N4O2 |
| Molecular Weight | 376.00 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Macitentan Standards
- Macitentan Impurity 54 (CAS CATO-C4X-117554)
- Macitentan Impurity 4 (CAS 2365406-85-3)
- Macitentan Impurity 45 (CAS CATO-C4X-117545)
- Macitentan Impurity 44 (CAS CATO-C4X-117544)
- Macitentan Impurity 22 (CAS 441797-83-7)
- Macitentan Impurity 39 (CAS CATO-C4X-117539)
- Macitentan Impurity 50 (CAS 2253990-09-7)
- Macitentan Impurity 41 (CAS CATO-C4X-117541)
Recommended Standards
- Ethyl 6,8-dibromo-2-oxo-2H-chromene-3-carboxylate (CAS 2199-89-5)
- 5-Bromo-2-iodo-n-methylbenzenesulfonamide (CAS 273208-20-1)
- Methyl 2-acetyl-5,7-dibromo-2H-indazole-6-carboxylate (CAS 1427460-31-8)
- 1,5-Diamino-2,4,6,8-tetrachloroanthracene-9,10-dione (CAS 83578-91-0)
- Rifapentine impurity 18 (CAS CATO-C4X-195918)
- Lercanidipine Impurity 9 (CAS 74936-72-4)
- Epinephrine Impurity 91 (CAS 78995-74-1)
- Potassium 2-methyl-5-nitrobenzenesulfonate (CAS 6671-50-7)
- N-(3,4-Dichlorophenyl)-3-(hydroxyamino)-3-iminopropanamide (CAS 763031-30-7)
- Methyl 3-(2-hydroxyphenyl)propiolate (CAS 425686-45-9)
- 2-(3-Ethoxyphenyl)-7,8-dimethylquinoline-4-carboxylic acid (CAS 895967-47-2)
- Phenyl (4-morpholino-6-propyl-1,3,5-triazin-2-yl)carbamate (CAS 127374-99-6)
- 1,2,3,4-Tetrahydroquinoline-5-sulfonamide (CAS 1155515-51-7)
- D-Ala35-Tirzepatide (CAS CATO-CPTD788904)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com