Macitentan Impurity 4 CAS 2365406-85-3
| CAS No. | 2365406-85-3 |
| Molecular Formula | C13H15BrN4O3S |
| Molecular Weight | 387.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Macitentan Impurity 4 (CAS 2365406-85-3), a pharmacopoeial impurity reference standard (molecular formula C13H15BrN4O3S, MW 387.25 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Macitentan Impurity 4 (C13H15BrN4O3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H15BrN4O3S |
| Molecular Weight | 387.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Macitentan Standards
- Macitentan Impurity 44 (CAS CATO-C4X-117544)
- Macitentan Impurity 22 (CAS 441797-83-7)
- Macitentan Impurity 17 (CAS 2211054-90-7)
- Macitentan Impurity 54 (CAS CATO-C4X-117554)
- Macitentan Impurity 45 (CAS CATO-C4X-117545)
- Macitentan Impurity 6 (CAS CATO-C4X-11756)
- Macitentan Impurity 20 (CAS CATO-C4X-117520)
- Macitentan Impurity 39 (CAS CATO-C4X-117539)
Recommended Standards
- 4-(4-Bromophenyl)-2-[4-(3-fluoropropoxy)phenyl]pyrimidine (CAS 477856-56-7)
- 4-(3,5-Dichlorobenzoyl)-8-ethyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326814-28-1)
- 2-(5-Bromo-2-methoxybenzylidene)benzo[4,5]imidazo[2,1-b]thiazol-3(2H)-one (CAS 329718-84-5)
- 4-(2,4-Dichlorobenzoyl)-8-ethyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326814-99-6)
- Clopidogrel Impurity 16 (CAS 138228-61-2)
- Prednisone Impurity 13 (CAS 97830-94-9)
- Glucosamine sulfate impurity 24 (CAS 6082-29-7)
- 1-cyclopropylpiperazine-2-carboxamide (CAS 1697661-89-4)
- 6-Bromo-5,7-dihydroxy-2-methyl-4H-chromen-4-one (CAS 2313569-89-8)
- 4,5-Dimethylpyrimidine-2-carbonitrile (CAS 114969-77-6)
- 2,5-Difluoro-4-methoxypyridine (CAS 1210868-65-7)
- Trimethyl 3,3',3''-phosphanetriyltripropionate hydrochloride (CAS 1304513-50-5)
- Methyl 2,5-dichloro-3-methylphenylacetate (CAS 1806348-10-6)
- Insulin Glargine Metabolite M2 (CAS CATO-CPTD788867)
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