Methyl 3-(4-ethoxyphenyl)propiolate CAS 221148-26-1
| CAS No. | 221148-26-1 |
| Molecular Formula | C12H12O3 |
| Molecular Weight | 204.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 204.22 g/mol gives Methyl 3-(4-ethoxyphenyl)propiolate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Methyl 3-(4-ethoxyphenyl)propiolate (CAS 221148-26-1), a certified reference material (molecular formula C12H12O3, MW 204.22 g/mol) for analytical method development and quality control.
The molecular framework of Methyl 3-(4-ethoxyphenyl)propiolate (C12H12O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12O3 |
| Molecular Weight | 204.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
Related Methyl Standards
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- 3-(4-Ethoxyphenyl)-1H-pyrazol-5(4H)-one (CAS 496923-27-4)
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Recommended Standards
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- 2-(4-Chlorophenyl)-3-nitrosoimidazo[1,2-a]pyrimidine (CAS 30469-02-4)
- 2-(Trifluoromethyl)-1,3-dioxaindan-2-amine (CAS 146628-55-9)
- 2-Chloro-4-(difluoromethyl)-5-fluoro-3-methylpyridine (CAS 1804672-52-3)
- 5-(Imidazo[1,2-a]pyridin-2-yl)-2-methylaniline (CAS 1706441-66-8)
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- Des-His(1)-Semaglutide (CAS CATO-C4X-2226216)
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