2-(Difluoromethoxy)-6-fluorobenzonitrile CAS 221202-14-8
| CAS No. | 221202-14-8 |
| Molecular Formula | C8H4F3NO |
| Molecular Weight | 187.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 187.12 g/mol gives 2-(Difluoromethoxy)-6-fluorobenzonitrile distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 2-(Difluoromethoxy)-6-fluorobenzonitrile (CAS 221202-14-8), a certified reference material (molecular formula C8H4F3NO, MW 187.12 g/mol) for analytical method development and quality control.
2-(Difluoromethoxy)-6-fluorobenzonitrile (C8H4F3NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 2-(Difluoromethoxy)-6-fluorobenzonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H4F3NO |
| Molecular Weight | 187.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethoxy Standards
- 2-(Difluoromethoxy)-5-fluorobenzonitrile (CAS 1017778-48-1)
- 4-(Difluoromethoxy)-2-fluorobenzonitrile (CAS 1017779-49-5)
- 5-(difluoromethoxy)-2-fluorobenzonitrile (CAS 1261499-62-0)
- 3-(Difluoromethoxy)-5-fluorobenzonitrile (CAS 1261674-63-8)
- 2-(Difluoromethoxy)-4-fluorobenzonitrile (CAS 933772-76-0)
- 4-(Difluoromethoxy)-3-fluorobenzonitrile (CAS 954388-59-1)
- 3-(Difluoromethoxy)-4-fluorobenzonitrile 916210-09-8 (CAS 916210-09-8)
- 6-(Difluoromethoxy)-4-methylnicotinaldehyde (CAS 1079352-17-2)
Recommended Standards
- 2-(Trifluoromethoxy)benzonitrile (CAS 63968-85-4)
- 1-azido-4-(trifluoromethyl)benzene (CAS 5586-13-0)
- 2-(Trifluoromethyl)-3H-imidazo[4,5-c]pyridine (CAS 19918-36-6)
- 1-azido-3-(trifluoromethyl)benzene (CAS 22001-17-8)
- 4-(1H-Benzimidazol-2-yl)-1-(3-methoxyphenyl)pyrrolidin-2-one (CAS 843622-05-9)
- Furaltadone (CAS 139-91-3)
- 2-Chloro-6-methoxypyrimidine-4-carbonitrile (CAS 1936326-00-9)
- 111963-87-2 5-Methoxy-3-(1-methyl-4-piperidinyl)indole 5-methoxy-3-(1-methylpiperidin-4-yl)-1H-indole (CAS 111963-87-2)
- 9-Ethyl-8-(hex-1-yn-1-yl)-9H-purin-6-amine (CAS 210046-42-7)
- N-acetyl-D-serine (CAS 152612-69-6)
- 2-(3-Chlorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one (CAS 361375-26-0)
- 1-(2-Chloro-4-fluorophenoxy)-3-(4-chlorobenzenesulfonyl)propan-2-ol (CAS 478079-78-6)
- (2R,3R)-1-Methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylic acid (CAS 162678-47-9)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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