2,3-Difluoro-6-methoxybenzonitrile CAS 221202-34-2
| CAS No. | 221202-34-2 |
| Molecular Formula | C8H5F2NO |
| Molecular Weight | 169.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2,3-Difluoro-6-methoxybenzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2,3-Difluoro-6-methoxybenzonitrile (CAS 221202-34-2), molecular formula C8H5F2NO and molecular weight 169.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2,3-Difluoro-6-methoxybenzonitrile (C8H5F2NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5F2NO |
| Molecular Weight | 169.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 2,5-Difluoro-4-methoxybenzonitrile (CAS 1007605-44-8)
- 3,6-Difluoro-2-methoxybenzonitrile (CAS 1010413-52-1)
- 3,5-Difluoro-4-methoxybenzonitrile (CAS 104197-15-1)
- 5,6-Difluoro-2,3-dihydro-1H-isoindol-1-one (CAS 1192040-50-8)
- 2,6-Difluoro-4-hydrazinobenzonitrile (CAS 1211514-57-6)
- 2,6-Difluoro-4-methoxybenzonitrile (CAS 123843-66-3)
- 2,4-Difluoro-6-methoxybenzonitrile (CAS 1240518-41-5)
- 3,4-Difluoro-5-methoxybenzonitrile (CAS 1262552-14-6)
Recommended Standards
- 2,3-Difluoro-4-methoxybenzonitrile (CAS 256417-12-6)
- 2,4-Difluoro-3-methoxybenzonitrile (CAS 220353-20-8)
- 2-(Hydroxymethyl)-6-nitrophenol (CAS 28177-71-1)
- 2,5-Difluoro-4-(hydroxymethyl)benzonitrile (CAS 433940-03-5)
- N-(3-cyano-5-phenylfuran-2-yl)-4-methyl-N-tosylbenzenesulfonamide (CAS 866017-61-0)
- 1-Benzyl-3-(trifluoromethyl)piperidin-4-amine (CAS 1356338-90-3)
- Diheptyl succinate (CAS 15872-89-6)
- 5-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile (CAS 1247726-68-6)
- 3-([(tert-Butoxy)carbonyl]amino)-4,4,4-trifluorobutanoic acid (CAS 1185296-42-7)
- (1-(Tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)methanamine (CAS 1344351-70-7)
- 1-(2,2,2-Trifluoroethyl)-1h-imidazole (CAS 91461-55-1)
- 1,10-Diazatricyclo[6.4.1.0,4,13]trideca-4,6,8(13)-triene (CAS 28740-91-2)
- Tert-butyl (1-((trimethylsilyl)ethynyl)cyclobutyl)carbamate (CAS 1268810-15-6)
- Semaglutide Impurity 161 (x TFA Salt) (CAS CATO-C4X-2226161)
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