2,3-Difluoro-6-hydroxybenzonitrile CAS 221202-36-4
| CAS No. | 221202-36-4 |
| Molecular Formula | C7H3F2NO |
| Molecular Weight | 155.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,3-Difluoro-6-hydroxybenzonitrile (CAS 221202-36-4), molecular formula C7H3F2NO and molecular weight 155.10 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2,3-Difluoro-6-hydroxybenzonitrile (C7H3F2NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3F2NO |
| Molecular Weight | 155.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 1,2-difluoro-3-isocyanatobenzene (CAS 1174233-36-3)
- 2,4-Difluoro-3-hydroxybenzonitrile (CAS 1214373-88-2)
- 2,6-difluoro-4-hydroxybenzonitrile (CAS 123843-57-2)
- 2,3-Difluoro-4-hydroxybenzonitrile (CAS 126162-38-7)
- 2,4-Difluoro-6-hydroxybenzonitrile (CAS 1261793-35-4)
- 1,1-Difluoro-3-nitrobutan-2-ol (CAS 129660-33-9)
- 2,5-Difluoro-3-hydroxybenzonitrile (CAS 1806367-92-9)
- 3,4-Difluoro-2-hydroxybenzonitrile (CAS 186590-34-1)
Recommended Standards
- 1-azido-2,4-difluorobenzene (CAS 91229-55-9)
- 2,5-Difluoro-4-hydroxybenzonitrile (CAS 887267-05-2)
- 1,3-Difluoro-5-isocyanatobenzene (CAS 83594-83-6)
- 2,6-Difluoro-3-hydroxybenzonitrile (CAS 946796-26-5)
- (S)-2-Amino-3-(methylthio)propanoic acid (CAS 66255-16-1)
- 5-Bromo-2-cyano-3-fluorobenzoic acid (CAS 1805523-28-7)
- N-Methylhex-5-en-1-amineHCl (CAS 862175-17-5)
- 4,5,6,7-tetrahydro-1H-1,2,3-benzotriazole-4-carboxylic acid (CAS 1509674-65-0)
- 937025-17-7 15-Acetylthio-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester MFCD11041102 (CAS 937025-17-7)
- 2-Cyclopropoxy-4-isopropyl-N-methylbenzamide (CAS 1243401-43-5)
- Ethyl (E)-2-cyano-3-phenylbut-2-enoate (CAS 14533-92-7)
- Hexadecyl carbonochloridate (CAS 26272-90-2)
- Ethyl 4-acetyl-3-methoxybenzoate (CAS 2062561-78-6)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
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