Ethyl 2-(6-chloro-2,2-dimethyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)acetate CAS 221225-76-9
| CAS No. | 221225-76-9 |
| Molecular Formula | C14H16ClNO4 |
| Molecular Weight | 297.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 2-(6-chloro-2,2-dimethyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)acetate (CAS 221225-76-9), molecular formula C14H16ClNO4 and molecular weight 297.73 g/mol, is a CATO reference standard with documented purity and traceability.
Ethyl 2-(6-chloro-2,2-dimethyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)acetate (C14H16ClNO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H16ClNO4 |
| Molecular Weight | 297.73 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- 1-(5-Chloro-2-methoxybenzoyl)piperidine-4-carboxylic acid (CAS 1016703-61-9)
- 6-chloro-2-(trifluoromethyl)-5-(trimethylsilyl)pyridine-3-carboxylic acid (CAS 1461705-32-7)
- 2-(4-Chloro-2-formylphenoxy)-N-((tetrahydrofuran-2-yl)methyl)acetamide (CAS 923161-84-6)
- 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one, 97% (CAS 1012884-46-6)
- 3-Benzyl-4-chloro-1-phenyl-1h-pyrrole-2,5-dione (CAS 1033200-81-5)
- 6-Chloro-2-(p-tolyl)quinoline-4-carboxylic acid, 97% (CAS 103914-61-0)
- 2-(2-Chloro-6-morpholino-7H-purin-8-yl)propan-2-ol (CAS 1198171-62-8)
- 6-Chloro-3-methyl-2-phenylquinoline-4-carboxylic acid (CAS 154869-06-4)
Recommended Standards
- Diethyl 2-(((3-chlorophenyl)amino)methylene)malonate (CAS 3412-99-5)
- 671216-07-2 4-(Chloromethyl)-5-methyl-2-(3,4,5-trimethoxyphenyl)-1,3-oxazole DTXSID20478803 (CAS 671216-07-2)
- Mivacurium chloride Impurity 37 (CAS 91248-14-5)
- 2-(2-Chlorobenzyl)-4,4-dimethyl-3-oxoisoxazolidin-5-yl acetate (CAS 81778-50-9)
- Chloro[2-di-<I>tert</I>-butyl(2′,4′,6′-triisopropylbiphenyl)phosphine] gold(I) (CAS 1312108-97-6)
- 7-Ethoxyisoquinoline-1-carbaldehyde (CAS 58402-45-2)
- 3-Chloro-N-(2,6-dimethylphenyl)propanamide (CAS 18085-76-2)
- 4-Amino-N-(9-oxo-9,10-dihydroacridin-3-yl)benzenesulfonamide (CAS 676456-14-7)
- [[2-(4-Ethylpiperazin-1-yl)-2-oxoethyl](phenyl)-amino]acetic acid (CAS 1142205-98-8)
- 5-Nitrofuran-3-carbaldehyde (CAS 72918-24-2)
- 1,3-Cyclohexanedione, 2-(cyclopropylcarbonyl)- (CAS 288258-62-8)
- 4-((3-Fluorophenyl)sulfonamido)benzoic acid (CAS 708293-25-8)
- 3-[4-(Trifluoromethoxy)phenyl]-pyridine-5-boronic acid (CAS 2121514-15-4)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com