Diethyl 2-(((3-chlorophenyl)amino)methylene)malonate CAS 3412-99-5
| CAS No. | 3412-99-5 |
| Molecular Formula | C14H16ClNO4 |
| Molecular Weight | 297.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Diethyl 2-(((3-chlorophenyl)amino)methylene)malonate (CAS 3412-99-5), molecular formula C14H16ClNO4 and molecular weight 297.73 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Diethyl 2-(((3-chlorophenyl)amino)methylene)malonate (C14H16ClNO4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Diethyl 2-(((3-chlorophenyl)amino)methylene)malonate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H16ClNO4 |
| Molecular Weight | 297.73 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diethyl Standards
- Diethyl 2-(((2-chlorophenyl)amino)methylene)malonate (CAS 19056-78-1)
- diethyl 2-[(4-chloroanilino)methylene]malonate (CAS 19056-79-2)
- Diethyl 3,3-dimethyl-4-(pyrrolidin-1-yl)cyclobutane-1,2-dicarboxylate (CAS 477725-46-5)
- Diethyl 2-amino-4,5,6,7-tetrahydrobenzo-[b]thiophene-3,5-dicarboxylate (CAS 1029689-49-3)
- Diethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3,4-dicarboxylate (CAS 175599-88-9)
- Diethyl 3-methyl-9-oxo-3-azabicyclo[3.3.1]Nonane-1,5-dicarboxylate (CAS 92727-60-1)
- Diethyl [1-(N-phthalimido)methyl]phosphonate, 97% (CAS 33512-26-4)
- 1,3-Diethyl 2-{[(1-carbamoylcyclopentyl)amino]methylidene}propanedioate (CAS 1035818-98-4)
Recommended Standards
- 2-(4-Chloro-2-formylphenoxy)-N-((tetrahydrofuran-2-yl)methyl)acetamide (CAS 923161-84-6)
- Ethyl 2-(6-chloro-2,2-dimethyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)acetate (CAS 221225-76-9)
- 2-(2-Chlorobenzyl)-4,4-dimethyl-3-oxoisoxazolidin-5-yl acetate (CAS 81778-50-9)
- 671216-07-2 4-(Chloromethyl)-5-methyl-2-(3,4,5-trimethoxyphenyl)-1,3-oxazole DTXSID20478803 (CAS 671216-07-2)
- Bis(prop-2-en-1-yl) oxalate (CAS 615-99-6)
- Methyl 3,3-difluoro-2,2-dimethylpropanoate (CAS 1849313-39-8)
- (S)-2-Amino-1-((S)-2-((benzyl(isopropyl)amino)methyl)pyrrolidin-1-yl)-3-methylbutan-1-one (CAS 1401664-91-2)
- (6R,7S)-7-(Benzoylamino)-3-(chloromethyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Diphenylmethyl Ester (CAS 1353648-24-4)
- (2-(2-(tert-Butylthio)pyridin-3-yl)piperidin-1-yl)(phenyl)methanone (CAS 1352540-62-5)
- 312693-16-6 3-Methoxybenzylzinc chloride, 0.5M in tetrahydrofuran MFCD01319883 (CAS 312693-16-6)
- (2-(Dimethyl(naphthalen-1-yl)silyl)phenyl)methanol (CAS 1217863-49-4)
- Levocetirizine Dihydrochloride - Impurity H (Hydrochloride Salt) (CAS 1177093-13-8)
- CAS 30718-13-9 (CAS 30718-13-9)
- Glucagon-like peptide 2 (CAS 89750-15-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com