Lomustine EP Impurity A CAS 2214-72-4

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.2214-72-4
Molecular FormulaC5H10Cl2N2O
Molecular Weight185.05 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Lomustine EP Impurity A CAS 2214-72-4 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 185.05 g/mol gives Lomustine EP Impurity A distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

As a process- or degradation-related impurity, Lomustine EP Impurity A (CAS 2214-72-4, C5H10Cl2N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Based on its molecular formula C5H10Cl2N2O, Lomustine EP Impurity A contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic functional-group stretching vibrations in infrared spectroscopy. The molecular weight of 185.05 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC5H10Cl2N2O
Molecular Weight185.05 g/mol
Purity>90%
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)1.0
CAS Registry Year (est.)1957
Halogen ContentCl-containing
Nitrogen Atoms2

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