Ruxolitinib Impurity 235 CAS 82504-43-6

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.82504-43-6
Molecular FormulaC6H10Cl2O2
Molecular Weight185.05 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Ruxolitinib Impurity 235 CAS 82504-43-6 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ruxolitinib Impurity 235.

Ruxolitinib Impurity 235 (CAS 82504-43-6) is a certified pharmaceutical impurity reference standard with the molecular formula C6H10Cl2O2 and a molecular weight of 185.05 g/mol.

The molecular framework of Ruxolitinib Impurity 235 (C6H10Cl2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC6H10Cl2O2
Molecular Weight185.05 g/mol
Purity≥95%
StorageStore at 2-8°C, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityContains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)1.0
CAS Registry Year (est.)1980
Halogen ContentCl-containing

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