Aripiprazole EP Impurity A CAS 22246-18-0
| CAS No. | 22246-18-0 |
| Molecular Formula | C9H9NO2 |
| Molecular Weight | 163.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Aripiprazole EP Impurity A is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Aripiprazole EP Impurity A (CAS 22246-18-0) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9NO2 and a molecular weight of 163.17 g/mol.
Based on its molecular formula C9H9NO2, Aripiprazole EP Impurity A contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 163.17 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9NO2 |
| Molecular Weight | 163.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 1 |
Related Aripiprazole Standards
- Aripiprazole Impurity 12 (CAS 52749-50-5)
- Aripiprazole Impurity 41 (CAS CATO-C4X-100841)
- Aripiprazole Impurity N3 (CAS 771-19-7)
- Aripiprazole Impurity N14 (2,6-quinolinediol) (CAS 19315-93-6)
- Aripiprazole Impurity N13 (CAS 48121-20-6)
- Aripiprazole Impurity 51 (CAS 69601-46-3)
- Aripiprazole Impurity 75 (CAS 1782324-31-5)
- Aripiprazole Impurity 86 (CAS CATO-C4X-100886)
Recommended Standards
- Cabazitaxel Impurity 22 (CAS 146924-92-7)
- Brexpiprazole Impurity 89 (CAS 15450-69-8)
- Cabazitaxel Impurity 21 (CAS 132127-34-5)
- Perindopril Impurity 39 (CAS 79815-20-6)
- Tegoprazan Impurity 80 (CAS CATO-C4X-229780)
- Gadobutrol Impurity 150 (CAS CATO-C4X-2120150)
- Ozagrel Impurity 22 (CAS CATO-C4X-197122)
- 4-(4-(Tert-butyl)phenoxy)-N,N-dimethyl-6-(trifluoromethyl)pyrimidin-2-amine (CAS 400086-55-7)
- 1-Methyl-3-azetidinemethanamine (CAS 1359656-98-6)
- Tert-butyl (3-fluoropropyl) carbonate (CAS 1980034-62-5)
- Ethyl 2,4-Dioxo-4-phenylbutanoate (CAS 6296-54-4)
- N-(2-Bromoethyl)-3,5-difluorobenzenesulfonamide (CAS 942473-84-9)
- N-Benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 679805-36-8)
- Immunstimulating Peptide, human (CAS 94773-24-7)
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