4-Chloro-7-(difluoromethoxy)quinazoline CAS 2225142-46-9
| CAS No. | 2225142-46-9 |
| Molecular Formula | C9H5ClF2N2O |
| Molecular Weight | 230.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-Chloro-7-(difluoromethoxy)quinazoline (CAS 2225142-46-9) is a high-purity analytical reference standard with the molecular formula C9H5ClF2N2O and a molecular weight of 230.60 g/mol.
4-Chloro-7-(difluoromethoxy)quinazoline (C9H5ClF2N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9H5ClF2N2O |
| Molecular Weight | 230.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-2-methoxyisophthalic acid (CAS 1100758-09-5)
- 2-Chloro-5-((trifluoromethyl)sulfinyl)pyrazine (CAS 1206524-07-3)
- 3-Chloro-6-((trifluoromethyl)sulfinyl)pyridazine (CAS 1206524-48-2)
- 2-Chloro-4-(trifluoromethyl)thiazole-5-carboxamide (CAS 151729-40-7)
- 2-Chloro-2,2-difluoro-1-(imidazo[1,2-a]pyridin-3-yl)ethan-1-one (CAS 219296-24-9)
- 6-chloro-2-(difluoromethyl)quinazolin-4-ol (CAS 50419-38-0)
- 4-Chloro-5-(trifluoromethyl)thiophene-2-carboxylic acid (CAS 1141015-47-5)
- 2-Chloro-4-(trifluoromethyl)thiophene-3-carboxylic acid (CAS 2732241-84-6)
Recommended Standards
- 3-(Chloromethyl)-5-(2,4-difluorophenyl)-1,2,4-oxadiazole (CAS 942035-93-0)
- 5-(Chloromethyl)-1-(3,4-difluorophenyl)-1h-tetrazole (CAS 941867-81-8)
- 2-(Chloromethyl)-5-(2,4-difluorophenyl)-1,3,4-oxadiazole (CAS 937633-19-7)
- Meclofenoxate Impurity 7 (CAS 2130-69-0)
- (R)-1-(tert-Butoxycarbonyl)-4-oxoazetidine-2-carboxylic acid (CAS 2771010-90-1)
- Ethyl 2-amino-4-(4-methoxyphenyl)-5-methylthiophene-3-carboxylate (CAS 350989-93-4)
- 2-(7-Ethyl-1-nitroso-3a,4-dihydro-1H-indol-3-yl)-ethanol (CAS CATO-C3D-26183)
- Acetamide-15N (CAS 1449-72-5)
- N-((5-(2,4-Difluorophenyl)isoxazol-3-yl)methyl)picolinamide (CAS 1211648-44-0)
- (6-(2,2,2-Trifluoroethyl)pyridin-3-yl)boronic acid (CAS 1356109-90-4)
- 5-Boc-2-Amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (CAS 365996-05-0)
- (6-Cyclobutoxypyrimidin-4-yl)methanamine (CAS 1439900-22-7)
- (+)-8-Demethylisoambrox (CAS 82079-83-2)
- Gastrin Tetrapeptide (CAS 1947-37-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com