Mefatinib Impurity 7 CAS 2225147-32-8
| CAS No. | 2225147-32-8 |
| Molecular Formula | C9H6F2N2O2 |
| Molecular Weight | 212.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Mefatinib Impurity 7 (C9H6F2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 212.15 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Mefatinib Impurity 7 (CAS 2225147-32-8, C9H6F2N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Mefatinib Impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H6F2N2O2 |
| Molecular Weight | 212.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Mefatinib Standards
- Mefatinib Impurity 5 (CAS 574738-64-0)
- Mefatinib Impurity 4 (CAS 1012057-47-4)
- Mefatinib Impurity 3 (CAS 53449-14-2)
- Mefatinib Impurity 17 (CAS CATO-C4X-299217)
- Mefatinib Impurity 18 (CAS CATO-C4X-299218)
- Mefatinib Impurity 2 (CAS 31374-18-2)
- Mefatinib Impurity 10 (CAS CATO-C4X-299210)
- Mefatinib Impurity 12 (CAS CATO-C4X-299212)
Recommended Standards
- Methyl 5,6-difluoro-2H-indazole-3-carboxylate (CAS 885279-01-6)
- Dimethyl 2-oxo-2H-pyran-4,6-dicarboxylate (CAS 104329-37-5)
- 6,8-Difluoro-7-hydroxy-4-methylcoumarin(DIFMU), 98% (CAS 215868-23-8)
- Methyl 4-amino-2-hydroxy-5-nitrobenzoate (CAS 106125-55-7)
- Orforglipron Impurity 49 (CAS CATO-C4X-323449)
- Posaconazole Impurity 200 (CAS CATO-C4X-1208200)
- Pazopanib Impurity 27 (CAS 6949-23-1)
- Tc-i 2000 (CAS 1159996-20-9)
- (4-Benzylthiomorpholin-3-yl)methanamine (CAS 170701-97-0)
- 4-(9h-Fluoren-3-yl)-4-oxobutanoic acid (CAS 339562-33-3)
- Rimegepant Impurity 2 DiHCl (CAS 781649-84-1)
- N2-(3,4-Dimethylphenyl)-6-((4-(3-methoxyphenyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine (CAS 701224-63-7)
- 2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-(2,3-dichlorophenyl)acetamide (CAS 481691-44-5)
- Semaglutide impurity 28 (CAS CATO-C4X-222628)
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