Mefatinib Impurity 3 CAS 53449-14-2
| CAS No. | 53449-14-2 |
| Molecular Formula | C8H4ClN3O3 |
| Molecular Weight | 225.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Mefatinib Impurity 3 (CAS 53449-14-2) is a certified pharmaceutical impurity reference standard with the molecular formula C8H4ClN3O3 and a molecular weight of 225.59 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Mefatinib Impurity 3 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 225.59 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4ClN3O3 |
| Molecular Weight | 225.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Mefatinib Standards
- Mefatinib Impurity 4 (CAS 1012057-47-4)
- Mefatinib Impurity 18 (CAS CATO-C4X-299218)
- Mefatinib Impurity 7 (CAS 2225147-32-8)
- Mefatinib Impurity 5 (CAS 574738-64-0)
- Mefatinib Impurity 17 (CAS CATO-C4X-299217)
- Mefatinib Impurity 10 (CAS CATO-C4X-299210)
- Mefatinib Impurity 12 (CAS CATO-C4X-299212)
- Mefatinib Impurity 14 (CAS CATO-C4X-299214)
Recommended Standards
- 6-Chloro-7-nitroquinoxalin-2-one (CAS 934690-33-2)
- 2-Chloro-7-fluoro-3-quinolinecarboxylic acid (CAS 1017157-81-1)
- 6-Chloro-2,3-dioxoindoline-5-carboxylic acid (CAS 828252-09-1)
- 2-Chloro-8-fluoroquinoline-3-carboxylic acid (CAS 1017378-95-8)
- Sacubitril impurity 53 (CAS CATO-C4X-280953)
- Erlotinib Impurity 87 (CAS CATO-C4X-106987)
- Resmetirom Impurity 45 (CAS CATO-C4X-291245)
- 2-Bromo-3-fluoroisonicotinaldehyde hydrate (CAS 1553621-71-8)
- 2-(4-(tert-Butyl)phenyl)-4-(piperidin-1-yl)quinoline hydrobromide (CAS 853343-81-4)
- N-(2,4-dimethylphenyl)-2-(2-formylphenoxy)acetamide (CAS 887357-71-3)
- 4-Tetrahydropyranyl Chloroformate (CAS 89641-80-5)
- N-(6-Methylpyridin-2-yl)acrylamide (CAS 919004-97-0)
- 4-Fluoro-3-(p-tolyl)-1H-pyrazol-5-amine (CAS 1420660-49-6)
- Tirzepatide Impurity 26 X TFA Salt (CAS CATO-C4X-324026)
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