(4-Chloro-2-cyclopropyl-5-(trifluoromethyl)phenyl)boronic acid CAS 2225173-00-0
| CAS No. | 2225173-00-0 |
| Molecular Formula | C10H9BClF3O2 |
| Molecular Weight | 264.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (4-Chloro-2-cyclopropyl-5-(trifluoromethyl)phenyl)boronic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(4-Chloro-2-cyclopropyl-5-(trifluoromethyl)phenyl)boronic acid (CAS 2225173-00-0), molecular formula C10H9BClF3O2 and molecular weight 264.44 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (4-Chloro-2-cyclopropyl-5-(trifluoromethyl)phenyl)boronic acid (C10H9BClF3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures (4-Chloro-2-cyclopropyl-5-(trifluoromethyl)phenyl)boronic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H9BClF3O2 |
| Molecular Weight | 264.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (2-Chloro-3-cyclopropyl-5-(trifluoromethyl)phenyl)boronic acid (CAS 2225169-22-0)
- (2-Chloro-4-cyclopropyl-5-(trifluoromethyl)phenyl)boronic acid (CAS 2225174-39-8)
- (2-Chloro-5-cyclopropyl-3-(trifluoromethyl)phenyl)boronic acid (CAS 2225172-16-5)
- 2-Chloro-4-iodonicotinonitrile (CAS 1171919-75-7)
- 6-Chloro-4-iodopicolinonitrile (CAS 1564978-89-7)
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- 2-Chloro-3-iodoisonicotinonitrile (CAS 908279-56-1)
- 2-Chloro-5-iodonicotinonitrile (CAS 766515-34-8)
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