(5-Chloro-6-(4-(trifluoromethyl)phenyl)pyridin-3-yl)boronic acid CAS 2225174-49-0

Purity 97%+In StockPharmaceutical Standards
CAS No.2225174-49-0
Molecular FormulaC12H8BClF3NO2
Molecular Weight301.46 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

(5-Chloro-6-(4-(trifluoromethyl)phenyl)pyridin-3-yl)boronic acid CAS 2225174-49-0 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 301.46 g/mol gives (5-Chloro-6-(4-(trifluoromethyl)phenyl)pyridin-3-yl)boronic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies (5-Chloro-6-(4-(trifluoromethyl)phenyl)pyridin-3-yl)boronic acid (CAS 2225174-49-0), a certified reference material (molecular formula C12H8BClF3NO2, MW 301.46 g/mol) for analytical method development and quality control.

The molecular framework of (5-Chloro-6-(4-(trifluoromethyl)phenyl)pyridin-3-yl)boronic acid (C12H8BClF3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), (5-Chloro-6-(4-(trifluoromethyl)phenyl)pyridin-3-yl)boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC12H8BClF3NO2
Molecular Weight301.46 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)7.5
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1998
Halogen ContentF/Cl-containing
Nitrogen Atoms1

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