2-(4-Fluorophenyl)-4-methylpyridine CAS 222551-24-8
| CAS No. | 222551-24-8 |
| Molecular Formula | C12H10FN |
| Molecular Weight | 187.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(4-Fluorophenyl)-4-methylpyridine (CAS 222551-24-8) is a high-purity analytical reference standard with the molecular formula C12H10FN and a molecular weight of 187.21 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, 2-(4-Fluorophenyl)-4-methylpyridine is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 187.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(4-Fluorophenyl)-4-methylpyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10FN |
| Molecular Weight | 187.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluorophenyl Standards
- 3-(4-Fluorophenyl)aniline (CAS 10540-45-1)
- 2-(2-Fluorophenyl)-4-methylpyridine (CAS 886444-12-8)
- 2-(4-Fluorophenyl)-5-methylpyridine (CAS 85237-65-6)
- 5-(3-Fluorophenyl)-2-methylpyridine (CAS 713143-67-0)
- 1-(4-Fluorophenyl)-1H-pyrazole-4-carbonitrile (CAS 1015862-36-8)
- 2-(((4-Fluorophenyl)amino)methylene)malononitrile (CAS 195243-31-3)
- 2-(((2-Fluorophenyl)amino)methylene)malononitrile (CAS 910418-34-7)
- N-(4-fluorophenyl)-N-methylcarbamoyl chloride (CAS 55239-51-5)
Recommended Standards
- 2-(5-Fluoro-2-methyl-1H-inden-3-yl)acetonitrile (CAS 1935539-76-6)
- 2-(Aminomethyl)-6-fluorospiro[3.3]heptane-2-carboxylic acid (CAS 2715120-06-0)
- 2-Benzyl-5-fluoropyridine (CAS 1934501-58-2)
- 2'-Fluoro-[1,1'-biphenyl]-2-amine (CAS 316-61-0)
- 3-(4-((2,5-Dihydro-1H-pyrrol-1-yl)methyl)benzoyl)benzonitrile (CAS 898763-85-4)
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- 2-[4-(Trifluoromethyl)furan-2-yl]acetic acid (CAS 1504300-33-7)
- 1-Bromoimidazo[1,5-c]pyrimidin-5(6H)-one (CAS 1784870-02-5)
- Neodymium boride (NdB6), (OC-6-11)- (CAS 12008-23-0)
- 2-Methyl-N-(1-(pyridin-3-yl)ethyl)propan-1-amine (CAS 1019628-91-1)
- 1,3,5-tris(4-Methoxyphenyl)-1,3,5-triazinane (CAS 32752-37-7)
- 4-Cyano-N-(5-methylthiazol-2-yl)benzamide (CAS 797016-38-7)
- Pancreatic Polypeptide (31-36), amide, human (CAS 74012-13-8)
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