4,4-Difluorotetrahydro-2H-pyran-2-carboxylic acid CAS 2227205-32-3
| CAS No. | 2227205-32-3 |
| Molecular Formula | C6H8F2O3 |
| Molecular Weight | 166.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4,4-Difluorotetrahydro-2H-pyran-2-carboxylic acid (C6H8F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4,4-Difluorotetrahydro-2H-pyran-2-carboxylic acid (CAS 2227205-32-3) is a high-purity analytical reference standard with the molecular formula C6H8F2O3 and a molecular weight of 166.12 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4,4-Difluorotetrahydro-2H-pyran-2-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H8F2O3 |
| Molecular Weight | 166.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
Related Difluorotetrahydro Standards
- 3,3-Difluorotetrahydro-2H-pyran-4-carboxylic acid (CAS 1504681-05-3)
- 7,7-Difluorotetrahydro-1H-Pyrrolo[1,2-c][1,3]Oxazol-3-One (CAS 173315-17-8)
- ((2R)-2,6-Difluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol (CAS 2838077-31-7)
- (R)-(2,2-Difluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol (CAS 2820537-02-6)
- (S)-(2,2-Difluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol (CAS 2820537-01-5)
- (1R)-1-(4,4-Difluorotetrahydro-2H-pyran-2-yl)propan-1-amine (CAS 2791312-22-4)
- (4,4-Difluorotetrahydro-2H-pyran-3-yl)methanol (CAS 1781098-50-7)
- (3,3-Difluorotetrahydro-2H-pyran-4-yl)methanol (CAS 1782291-14-8)
Recommended Standards
- 4-(Difluoromethyl)-4-hydroxytetrahydro-2h-pyran-2-one (CAS 83191-82-6)
- 4-Ethynyl-2,6-difluorobenzaldehyde (CAS 2242425-12-1)
- 3-Fluoropropanoic anhydride (CAS 2266-47-9)
- Ethyl 2,2-Difluoro-3-oxobutanoate (CAS 2266-48-0)
- (4R)-α-[(4R)-4,5-Dihydro-4-phenyl-2-oxazolyl]-4,5-dihydro-4-phenyl-2-oxazoleacetonitrile (CAS 1442644-12-3)
- 2-[(4-Hydroxybenzyl)amino]-N,N-dimethylethanesulfonamide oxalate (CAS 1332531-24-4)
- Methyl4-cyanocyclohexanecarboxylate (CAS 32529-82-1)
- Spiro[isochroman-1,4'-piperidine] hydrochloride (CAS 173943-98-1)
- 4-Fluoro-n-methyl-n'-(3-methyl-1-phenyl-1h-pyrazol-5-yl)benzene-1-carboximidamide (CAS 380394-41-2)
- 4-bromo-N-(thiophen-2-ylmethyl)aniline (CAS 116360-53-3)
- 3-(tert-Butyl)-1-(p-tolyl)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (CAS 1284848-13-0)
- (2-(3-Chlorophenyl)oxazol-4-yl)methanol (CAS 885272-83-3)
- N-(Phenylmethoxy)-3-buten-1-amine (CAS 1489935-88-7)
- β-Asp9-Tirzepatide (CAS CATO-CPTD788931)
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