Ethyl 2,2-Difluoro-3-oxobutanoate CAS 2266-48-0
| CAS No. | 2266-48-0 |
| Molecular Formula | C6H8F2O3 |
| Molecular Weight | 166.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ethyl 2,2-Difluoro-3-oxobutanoate is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ethyl 2,2-Difluoro-3-oxobutanoate (CAS 2266-48-0) is a high-purity analytical reference standard with the molecular formula C6H8F2O3 and a molecular weight of 166.12 g/mol.
The molecular framework of Ethyl 2,2-Difluoro-3-oxobutanoate (C6H8F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H8F2O3 |
| Molecular Weight | 166.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Ethyl Standards
- 2,2-difluoro-2-(furan-2-yl)acetic acid (CAS 1344257-62-0)
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- 3,3-Difluoro-4-Methyl-2-Oxopentanoic Acid (CAS 165544-39-8)
- 2,2-Difluoro-2-(tetrahydrofuran-2-yl)acetic acid (CAS 170884-47-6)
- 2,2-Difluoro-2-(tetrahydrofuran-3-yl)acetic acid (CAS 1781025-79-3)
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