2-Chloro-3-methyl-5-nitropyridine CAS 22280-56-4
| CAS No. | 22280-56-4 |
| Molecular Formula | C6H5ClN2O2 |
| Molecular Weight | 172.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 172.57 g/mol gives 2-Chloro-3-methyl-5-nitropyridine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-Chloro-3-methyl-5-nitropyridine (CAS 22280-56-4), molecular formula C6H5ClN2O2 and molecular weight 172.57 g/mol, is a CATO reference standard with documented purity and traceability.
2-Chloro-3-methyl-5-nitropyridine (C6H5ClN2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-3-methyl-5-nitropyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H5ClN2O2 |
| Molecular Weight | 172.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-Chloro-5-methyl-2-nitropyridine (CAS 1210909-07-1)
- 6-Chloro-3-methyl-2-nitropyridine (CAS 1211516-41-4)
- 6-Chloro-5-methyl-3-pyridazinecarboxylic acid (CAS 1211516-60-7)
- 6-Chloro-N-hydroxypyridine-2-carboxamide (CAS 125309-38-8)
- Methyl 5-chloro-3-pyridazinecarboxylate (CAS 1256786-31-8)
- 6-Chloro-N-hydroxynicotinamide (CAS 1263094-64-9)
- 5-Chloro-N-hydroxypicolinamide (CAS 1289026-43-2)
- 6-Chloro-2-methylpyrimidine-4-carboxylic acid (CAS 136518-06-4)
Recommended Standards
- 2-Chloro-3-methyl-4-nitropyridine (CAS 79055-56-4)
- 2-Chloro-3-nitroaniline (CAS 3970-41-0)
- 2-Chloro-3-hydroxybenzoic acid (CAS 51786-10-8)
- 2-Chloro-4,5-dihydroxybenzaldehyde (CAS 37686-56-9)
- 2-Hydroxy-6-(methylamino)benzenesulfonamide (CAS 1243458-32-3)
- (E)-3-methyl-6-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)-3H-imidazo[4,5-b]pyridine (CAS 2377233-86-6)
- 2-Aminocinnamic acid (CAS 1664-63-7)
- 5-Methoxy-3-methylpicolinaldehyde (CAS 1256813-09-8)
- 5-(Dimethylcarbamoyl)-2-hydroxybenzoic acid (CAS 1243454-31-0)
- 2-(2-Chloro-5-methylphenoxy)acetic acid (CAS 1556-00-9)
- (2R,3R,4S,5R,6R)-5-(benzyloxy)-2-((benzyloxy)methyl)-6-methoxytetrahydro-2H-pyran-3,4-diol (CAS 51842-27-4)
- 5-(2,4-Difluorophenyl)oxazolidin-2-one (CAS 1494490-18-4)
- 1-Amino-[1,2,4]triazolo[4,3-a]quinazolin-5(3H)-one (CAS 404578-73-0)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com