2,4-Diamino-6-hydroxy-5-thiocyanopyrimidine CAS 22288-75-1
| CAS No. | 22288-75-1 |
| Molecular Formula | C5H5N5OS |
| Molecular Weight | 183.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2,4-Diamino-6-hydroxy-5-thiocyanopyrimidine (C5H5N5OS) is characterized by an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2,4-Diamino-6-hydroxy-5-thiocyanopyrimidine (CAS 22288-75-1) is a high-purity analytical reference standard with the molecular formula C5H5N5OS and a molecular weight of 183.19 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H5N5OS |
| Molecular Weight | 183.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Diamino Standards
- 2,5-Diamino-6-(dimethylamino)-3-methylpyrimidin-4(3H)-one (CAS 61693-34-3)
- 5,6-Diamino-2-(dimethylamino)-3-methylpyrimidin-4(3H)-one (CAS 61693-37-6)
- Ethyl 1,2-diamino-4-methyl-1H-pyrrole-3-carboxylate (CAS 458527-73-6)
- N-(2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-N-methylformamide (CAS 77440-13-2)
- 3,4-Diamino-5-(difluoromethyl)picolinonitrile (CAS 1805012-02-5)
- 3,5-Diamino-6-(difluoromethyl)picolinonitrile (CAS 1805012-05-8)
- 3,6-Diamino-4-(difluoromethyl)picolinonitrile (CAS 1806786-53-7)
- 3,6-Diamino-2-(difluoromethyl)isonicotinonitrile (CAS 1806811-58-4)
Recommended Standards
- 2-(Methylsulfonyl)pyrimidine-5-carbonitrile (CAS 38275-50-2)
- 2,5-Diaminothiazolo[4,5-d]pyrimidin-7(4H)-one (CAS 22288-77-3)
- 2-(((1,1,1,3,3,3-Hexafluoro-2-(2,3,5,6-tetrafluorophenyl)propan-2-yl)oxy)methyl)oxirane (CAS 28180-40-7)
- 2-Amino-6-hydroxy-8-mercaptopurine (CAS 6324-72-7)
- 7-Chloro-2,2,4,4-tetrafluoro-4H-benzo[d][1,3]dioxine (CAS 25854-54-0)
- 4-(Aminomethyl)-2-methylbenzenesulfonamide Hydrochloride (CAS 1787855-08-6)
- 6-Fluoro-2-(phenylsulfonyl)-1H-indole (CAS 1505521-55-0)
- Methyl (2-(3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl)ethyl)carbamate (CAS 1797237-93-4)
- 2-(7-Bromo-1H-benzo[d]imidazol-6-yl)acetonitrile (CAS 1803895-20-6)
- 4-(1-Boc-1,2,3,6-tetrahydro-4-pyridyl)-2-methyl-6-nitroaniline (CAS 1054315-49-9)
- (5-Chloro-2-fluoro-3-methoxyphenyl)(methyl)sulfane (CAS 1452479-02-5)
- Ethyl 4-hydroxy-2-(methoxymethyl)pyrimidine-5-carboxylate (CAS 69731-52-8)
- 3-{[3-(Aminocarbonyl)piperidin-1-yl]carbonyl}-2,2-dimethylcyclopropanecarboxylic acid (CAS 1186653-79-1)
- Semaglutide（sodium salt） (CAS CATO-C4X-222619)
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