2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione CAS 22288-66-0
| CAS No. | 22288-66-0 |
| Molecular Formula | C8H6N2O2 |
| Molecular Weight | 162.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione (CAS 22288-66-0) is a high-purity analytical reference standard with the molecular formula C8H6N2O2 and a molecular weight of 162.15 g/mol.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 162.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6N2O2 |
| Molecular Weight | 162.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 2 |
Recommended Standards
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- 5-Chloropyridazine-3-carboxylic acid (CAS 1211587-01-7)
- 2-(2-Chloro-3-nitrophenyl)acetonitrile (CAS 108772-95-8)
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- (S)-2-Amino-3-((S)-1-methyl-2,4-dioxohexahydropyrimidin-5-yl)propanoic acid (CAS 326891-09-2)
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