ethyl 2-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-2,2-difluoro-acetate CAS 2230727-39-4
| CAS No. | 2230727-39-4 |
| Molecular Formula | C11H17F2NO4 |
| Molecular Weight | 265.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
ethyl 2-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-2,2-difluoro-acetate (CAS 2230727-39-4) is a high-purity analytical reference standard with the molecular formula C11H17F2NO4 and a molecular weight of 265.25 g/mol.
The molecular framework of ethyl 2-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-2,2-difluoro-acetate (C11H17F2NO4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), ethyl 2-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-2,2-difluoro-acetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H17F2NO4 |
| Molecular Weight | 265.25 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related ethyl Standards
- Methyl 1-(6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carbonyl)azetidine-3-carboxylate (CAS 1421443-44-8)
- 10-(3,6-Dihydro-2H-pyran-3-yl)-10H-phenoxazine (CAS 2079095-65-9)
- 4-(3-Phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzamide (CAS 61447-65-2)
- [2-(3,4-Dihydro-2H-quinolin-1-yl)-2-oxo-ethylsulfanyl]acetic acid (CAS 380545-88-0)
- 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(pentan-3-yl)amino]ethan-1-ol (CAS 1179170-70-7)
- 4,5-Dihydro-4,4-dimethyl-2-(4′-methyl[1,1′-biphenyl]-3-yl)oxazole (CAS 1810071-88-5)
- 4,5-Dihydro-4,4-dimethyl-2-(4′-methyl[1,1′-biphenyl]-4-yl)oxazole (CAS 383185-74-8)
- 3,4-Dihydro-3,3-dimethyl-N-(2-methylphenyl)-1-isoquinolinamine (CAS 328089-07-2)
Recommended Standards
- 4-((Tert-butoxycarbonyl)amino)-3,3-difluorocyclopentane-1-carboxylic acid (CAS 2168119-43-3)
- Ethyl 6-(methylthio)-2-(trifluoromethyl)nicotinate (CAS 261635-84-1)
- 2,2,2-Trifluoroethyl n-[4-(methylsulfanyl)phenyl]carbamate (CAS 464935-24-8)
- Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate (CAS 647857-74-7)
- 1-(4-Methoxythiophen-2-yl)ethan-1-one (CAS 34694-78-5)
- ((2,3-Dichlorophenyl)sulfonyl)tryptophan (CAS 1008024-83-6)
- 1-(5-Chloro-2-hydroxybenzyl)pyrrolidine-3-carboxylic acid (CAS 1479908-62-7)
- 3-Chloro-6-methyl-1H-indene-2-carbaldehyde (CAS 1314802-45-3)
- 2-(2,2-Dibromovinyl)furan (CAS 100074-10-0)
- 35231-57-3 Pyrimidine, 5-ethoxy-2-methyl- (9CI) (CAS 35231-57-3)
- (2E,6E)-8-(1,4-Dimethoxy-3-methylnaphthalen-2-yl)-2,6-dimethylocta-2,6-dien-1-ol 6285AC 94828-05-4 C23H30O3 (CAS 94828-05-4)
- (S)-3-Acetyl-1-Boc-pyrrolidine (CAS 1374673-89-8)
- 6-Chloro-3-(difluoromethyl)pyridine-2,5-diamine (CAS 1806786-34-4)
- Biotinyl-S6 Phosphate Acceptor Peptide trifluoroacetate salt (CAS 1815618-12-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com