2-(Chloromethyl)-3-(4-methylphenyl)quinazolin-4(3H)-one CAS 22312-80-7

Purity 97%+In StockPharmaceutical Standards
CAS No.22312-80-7
Molecular FormulaC16H13ClN2O
Molecular Weight284.74 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(Chloromethyl)-3-(4-methylphenyl)quinazolin-4(3H)-one CAS 22312-80-7 chemical structure

Description

The occurrence of 2-(Chloromethyl)-3-(4-methylphenyl)quinazolin-4(3H)-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

2-(Chloromethyl)-3-(4-methylphenyl)quinazolin-4(3H)-one (CAS 22312-80-7), molecular formula C16H13ClN2O and molecular weight 284.74 g/mol, is a CATO reference standard with documented purity and traceability.

2-(Chloromethyl)-3-(4-methylphenyl)quinazolin-4(3H)-one (C16H13ClN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-(Chloromethyl)-3-(4-methylphenyl)quinazolin-4(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC16H13ClN2O
Molecular Weight284.74 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)11.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1963
Halogen ContentCl-containing
Nitrogen Atoms2

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