2-(Chloromethyl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one CAS 22312-81-8
| CAS No. | 22312-81-8 |
| Molecular Formula | C16H13ClN2O2 |
| Molecular Weight | 300.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures 2-(Chloromethyl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
2-(Chloromethyl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one (CAS 22312-81-8) is a high-purity analytical reference standard with the molecular formula C16H13ClN2O2 and a molecular weight of 300.74 g/mol.
The molecular framework of 2-(Chloromethyl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one (C16H13ClN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C16H13ClN2O2 |
| Molecular Weight | 300.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloromethyl Standards
- 2-(Chloromethyl)-3-(4-methoxyphenyl)quinazolin-4(3H)-one (CAS 22312-82-9)
- 8-(Chloromethyl)-7-(2-methoxyethyl)-3-propyl-2,3,6,7-tetrahydro-1h-purine-2,6-dione (CAS 853724-00-2)
- 4-(2-(Chloromethyl)oxazol-5-yl)-N,N-dimethylbenzenesulfonamide (CAS 89102-57-8)
- Ethyl 6-(chloromethyl)-2-oxo-4-(thiophen-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 878465-42-0)
- 2-(Chloromethyl)-2-methyl-3-(p-tolyl)-2,3-dihydroquinazolin-4(1H)-one (CAS 217461-89-7)
- 2-(Chloromethyl)-4-(difluoromethyl)-5-(trifluoromethoxy)pyridine-3-acetonitrile (CAS 1804750-82-0)
- 2-(Chloromethyl)-4-(difluoromethyl)-3-(trifluoromethoxy)pyridine-6-acetonitrile (CAS 1804908-15-3)
- 2-(Chloromethyl)-4-(difluoromethyl)-3-(trifluoromethoxy)pyridine-5-acetonitrile (CAS 1805306-42-6)
Recommended Standards
- 2-(4-Chlorophenyl)-N-(2-oxoindolin-5-yl)acetamide (CAS 921544-79-8)
- 2-(4-Chlorobenzoyl)-6-methoxy-3-methyl-1-benzofuran (CAS 303145-33-7)
- 2-[3-(4-chloro-2-methylphenoxymethyl)-1H-1,2,4-triazol-5-yl]pyridine (CAS 620934-98-7)
- 2-(4-Chlorobenzoyl)-5-methoxy-3-methyl-1-benzofuran (CAS 303145-45-1)
- 1,3-Dichloro-5-(trifluoromethyl)benzene (CAS 54773-20-5)
- 3-(4-Methoxyphenoxy)azetidine hydrochloride (CAS 1236862-34-2)
- Ethyl 2-(pyridin-3-yl)-6-(trifluoromethyl)nicotinate (CAS 1214361-54-2)
- N-(2-amino-5-methoxyphenyl)isobutyramide (CAS 903822-32-2)
- (7-Methoxynaphthalen-2-yl)methanamine (CAS 1261505-43-4)
- 2-(4-Bromo-6-chloro-2-(difluoromethyl)pyridin-3-yl)acetonitrile (CAS 1805394-39-1)
- 3-(2,2,2-Trifluoroethoxy)pyridin-2-amine (CAS 1037160-20-5)
- 2-(4-Bromo-3-methylphenyl)benzo[d]oxazol-5-amine (CAS 354561-72-1)
- 2-(1H-pyrazol-4-yl)quinoline 4-(Quinolin-2-yl)-1H-pyrazole 439106-87-3 (CAS 439106-87-3)
- Neuropeptide Y (3-36) (human, rat) trifluoroacetate salt (CAS 150138-78-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com