5-Chloro-4-(difluoromethoxy)pyridin-2-amine CAS 2231672-98-1
| CAS No. | 2231672-98-1 |
| Molecular Formula | C6H5ClF2N2O |
| Molecular Weight | 194.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Chloro-4-(difluoromethoxy)pyridin-2-amine (CAS 2231672-98-1) is a high-purity analytical reference standard with the molecular formula C6H5ClF2N2O and a molecular weight of 194.57 g/mol.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 5-Chloro-4-(difluoromethoxy)pyridin-2-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 194.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5ClF2N2O |
| Molecular Weight | 194.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 6-Chloro-4-(difluoromethoxy)pyridin-2-amine (CAS 1677685-18-5)
- 2-Chloro-6-(difluoromethyl)pyrimidine-4,5-diamine (CAS 1706444-59-8)
- 5-Chloro-6-(difluoromethyl)-2-methylpyrimidin-4(3H)-one (CAS 1707378-61-7)
- 2-Chloro-5-(difluoromethoxy)-4-methylpyrimidine (CAS 1823916-35-3)
- 2-Chloro-2-oxoethane-1,1-diyl diacetate (CAS 36674-73-4)
- 3-Chloro-4-(difluoromethoxy)pyridin-2-amine (CAS 2231676-69-8)
- 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde (CAS 660845-30-7)
- 4-Chloro-3-(difluoromethoxy)phenol (CAS 1261440-11-2)
Recommended Standards
- 2-Chloro-6-methylbenzotrifluoride 1-Chloro-3-methyl-2-(trifluoromethyl)benzene 112641-25-5 (CAS 112641-25-5)
- 5-Amino-3-chloro-1-(difluoromethyl)pyridin-2(1H)-one (CAS 2661482-99-9)
- 2-Chloro-4-(1,1-difluoroethyl)-1-fluorobenzene (CAS 1138444-93-5)
- 1-Chloro-3-methyl-5-(trifluoromethyl)benzene (CAS 1214384-22-1)
- 6-Bromo-4-fluoro-2,3-dihydroinden-1-one (CAS 881189-74-8)
- 2-Amino-4,6-dimethylbenzonitrile (CAS 35490-77-8)
- 1-[(3-Chlorophenyl)methyl]-2-oxo-N-(1,3-thiazol-2-yl)-1,2-dihydropyridine-3-carboxamide (CAS 339008-72-9)
- <I>N</I>,<I>N</I>′-Bis(salicylidene)-1,3-propanediamine (CAS 120-70-7)
- (R)-4-Bromo-3-(2-oxiranyl)-phenol 1-O-(2-Methoxyethoxymethyl) Ether 1798807-29-0 (CAS 1798807-29-0)
- Benzyl ethyl(piperidin-2-ylmethyl)carbamate (CAS 1353944-36-1)
- 2-(oxolan-3-yl)-1H-1,3-benzodiazole (CAS 906519-35-5)
- 2-Cyano-3-(3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl)acrylic acid (CAS 1006492-24-5)
- 4-Bromo-6-methoxy-1,5-naphthyridin-3-amine (CAS 724788-66-3)
- Insulin Degludec Impurity 7 (CAS CATO-C4X-21577)
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