5-Amino-3-chloro-1-(difluoromethyl)pyridin-2(1H)-one CAS 2661482-99-9

Purity 97%+In StockPharmaceutical Standards
CAS No.2661482-99-9
Molecular FormulaC6H5ClF2N2O
Molecular Weight194.57 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

5-Amino-3-chloro-1-(difluoromethyl)pyridin-2(1H)-one CAS 2661482-99-9 chemical structure

Description

Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.

5-Amino-3-chloro-1-(difluoromethyl)pyridin-2(1H)-one (CAS 2661482-99-9) is a high-purity analytical reference standard with the molecular formula C6H5ClF2N2O and a molecular weight of 194.57 g/mol.

The molecular framework of 5-Amino-3-chloro-1-(difluoromethyl)pyridin-2(1H)-one (C6H5ClF2N2O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

As a certified reference material (CRM), 5-Amino-3-chloro-1-(difluoromethyl)pyridin-2(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC6H5ClF2N2O
Molecular Weight194.57 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2002
Halogen ContentF/Cl-containing
Nitrogen Atoms2

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