1-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)piperazine CAS 22365-08-8
| CAS No. | 22365-08-8 |
| Molecular Formula | C21H21F3N2S |
| Molecular Weight | 390.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)piperazine.
As a process- or degradation-related impurity, 1-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)piperazine (CAS 22365-08-8, C21H21F3N2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
1-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)piperazine (C21H21F3N2S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures 1-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)piperazine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H21F3N2S |
| Molecular Weight | 390.47 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related trifluoromethyl Standards
- Benzyl 5-(trifluoromethyl)spiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 1243328-71-3)
- 4-[3,5-Bis(trifluoromethyl)phenyl]-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol (CAS 1170510-97-0)
- 3-[2,5-bis(trifluoromethyl)phenyl]-2-sulfanyl-3,4-dihydroquinazolin-4-one (CAS 722465-84-1)
- 4,4-Bis(trifluoromethyl)-5,5,6,6,7,7,7-heptafluorohept-2-enoic acid (CAS 261503-43-9)
- 2-({2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}sulfanyl)-4-(trifluoromethyl)pyrimidine-5-carbonitrile (CAS 400077-06-7)
- 2-({2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl}sulfanyl)-4-(trifluoromethyl)pyrimidine-5-carbonitrile (CAS 400079-37-0)
- Methyl 2-({2-[2-(trifluoromethyl)-1H-1,3-benzimidazol-1-yl]propanoyl}amino)benzenecarboxylate (CAS 692732-71-1)
- 2-Phenyl-1-[5-(1-{[3-(trifluoromethyl)pyridin-2-yl]sulfanyl}ethyl)-1H-pyrazol-1-yl]ethan-1-one (CAS 1211305-28-0)
Recommended Standards
- Flupentixol Impurity 31 (CAS CATO-C4X-189531)
- Evocalcet Impurity 32 (CAS CATO-C4X-248532)
- Indacaterol Impurity 36 (CAS CATO-C4X-150036)
- Evocalcet Impurity 37 (CAS CATO-C4X-248537)
- Dexamethasone Impurity 117 (CAS CATO-C4X-1165117)
- Mosapride Impurity 52 (CAS CATO-C4X-104452)
- Loratadine Impurity 65 (CAS CATO-C4X-142665)
- 5-(2-Chloro-6-methylphenyl)-2H-tetrazole (CAS 175205-13-7)
- 6-Methoxy-N-((5-methylfuran-2-yl)methyl)pyridin-3-amine (CAS 1019490-69-7)
- (s)-2-Amino-2-(2-(dimethylamino)phenyl)ethan-1-ol (CAS 1212831-75-8)
- tert-Butyl 4-(2-nitrobenzyl)piperazine-1-carboxylate (CAS 1197539-94-8)
- 3-((4-Methoxyphenoxy)methyl)pyrrolidine (CAS 933736-44-8)
- N-(6-bromo-2-(((tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridin-7-yl)pivalamide (CAS 1171920-45-8)
- Tirzepatide Impurity 18 (CAS CATO-C4X-324018)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com