6-Amino-5-(2-chloroacetyl)-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione CAS 22365-19-1

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Amino-5-(2-chloroacetyl)-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione.

6-Amino-5-(2-chloroacetyl)-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 22365-19-1) is a high-purity analytical reference standard with the molecular formula C7H8ClN3O3 and a molecular weight of 217.61 g/mol.

Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 6-Amino-5-(2-chloroacetyl)-1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 217.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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