2-(2-Chlorophenyl)-5-phenyloxazole CAS 22397-40-6
| CAS No. | 22397-40-6 |
| Molecular Formula | C18H22ClNO2 |
| Molecular Weight | 319.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(2-Chlorophenyl)-5-phenyloxazole (CAS 22397-40-6) is a high-purity analytical reference standard with the molecular formula C18H22ClNO2 and a molecular weight of 319.83 g/mol.
The molecular framework of 2-(2-Chlorophenyl)-5-phenyloxazole (C18H22ClNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 2-(2-Chlorophenyl)-5-phenyloxazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H22ClNO2 |
| Molecular Weight | 319.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorophenyl Standards
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Recommended Standards
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- (3-(Benzyloxy)-2-chlorophenyl)(tert-butylamino)methanol (CAS 1415559-72-6)
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- (3-Amino-3-phenylpropyl)dimethylamine dihydrochloride (CAS 1185018-68-1)
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- Carbonyl sulfide (CAS 463-58-1)
- 2-(Trifluoromethoxy)pyridin-4-amine (CAS 1221172-01-5)
- Methyl 4-Benzyl-3-morpholinecarboxylate (CAS 212650-44-7)
- 4-Chloro-8-methoxyquinazoline (CAS 154288-09-2)
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- (3,5-Dimethyl-1H-pyrazol-1-yl)(1-ethyl-3-(piperidin-1-ylsulfonyl)-1H-pyrazol-4-yl)methanone (CAS 1261009-54-4)
- Protein Kinase C (alpha) Peptide (CAS 159939-84-1)
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