1,3-Difluoro-2-(4-fluorophenoxy)-5-(trifluoromethyl)benzene CAS 2244084-61-3
| CAS No. | 2244084-61-3 |
| Molecular Formula | C13H6F6O |
| Molecular Weight | 292.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1,3-Difluoro-2-(4-fluorophenoxy)-5-(trifluoromethyl)benzene.
CATO supplies 1,3-Difluoro-2-(4-fluorophenoxy)-5-(trifluoromethyl)benzene (CAS 2244084-61-3), a certified reference material (molecular formula C13H6F6O, MW 292.18 g/mol) for analytical method development and quality control.
The molecular framework of 1,3-Difluoro-2-(4-fluorophenoxy)-5-(trifluoromethyl)benzene (C13H6F6O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1,3-Difluoro-2-(4-fluorophenoxy)-5-(trifluoromethyl)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H6F6O |
| Molecular Weight | 292.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 1,3-Difluoro-2-(2-fluorophenoxy)-5-(trifluoromethyl)benzene (CAS 2244086-79-9)
- 1,3-Difluoro-2-(3-fluorophenoxy)-5-(trifluoromethyl)benzene (CAS 2244087-52-1)
- 3',5-Difluoro-4'-(methoxycarbonyl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261898-53-6)
- 2',3-Difluoro-5'-(methoxycarbonyl)-[1,1'-biphenyl]-4-carboxylic acid (CAS 1261912-20-2)
- 6,8-Difluoro-4-methylumbelliferylphosphate (CAS 214491-43-7)
- 4-(2,6-Difluoro-3-bromobenzyl)morpholine (CAS 1428234-63-2)
- 5,5-Difluoro-9-(2-methoxy-2-oxoethyl)-3,7-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide (CAS 126250-45-1)
- 2,4-Difluoro-3-(2-thiomethylphenyl)propiophenone (CAS 898780-57-9)
Recommended Standards
- 1-[(1Z)-{[(2,4-dichlorophenyl)methoxy]imino}methyl]-3-methylthiourea (CAS 338976-97-9)
- 2-(3,5-Dimethoxy-2,6-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2096469-97-3)
- 3-Methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-boronic Acid Pinacol Ester (CAS 1853186-01-2)
- 2-(3-Isopropoxy-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 944332-89-2)
- 1,1',1''-(Nitrilotris(benzene-4,1-diyl))triethanone (CAS 4181-21-9)
- Methyl 5-amino-5,6,7,8-tetrahydronaphthalene-1-carboxylate (CAS 774518-42-2)
- 5-Bromo-2-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-inden-1-one (CAS 1373824-01-1)
- 3-bromo-6-fluoro-1H-pyrrolo[2,3-b]pyridine (CAS 1190315-22-0)
- 6,7-dimethyl-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid (CAS 1159830-81-5)
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- 3-(3,4-Dihydroxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (CAS 92496-89-4)
- D-Tyr1-Tirzepatide (CAS CATO-CPTD788928)
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