2-(3-Chlorophenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene CAS 2244084-63-5
| CAS No. | 2244084-63-5 |
| Molecular Formula | C13H6ClF5O |
| Molecular Weight | 308.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(3-Chlorophenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene (C13H6ClF5O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
2-(3-Chlorophenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene (CAS 2244084-63-5), molecular formula C13H6ClF5O and molecular weight 308.63 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H6ClF5O |
| Molecular Weight | 308.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
Related Chlorophenoxy Standards
- 2-(2-Chlorophenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene (CAS 2244086-85-7)
- 2-(4-Chlorophenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene (CAS 2244087-56-5)
- 4-(4-Chlorophenoxy)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine (CAS 339018-86-9)
- 3-(2-Chlorophenoxy)-6-phenylpyridazine-4-carbonitrile (CAS 338751-75-0)
- 3-(4-chlorophenoxy)-6-phenyl-4-pyridazinecarbonitrile 338751-61-4 KS-000038TF (CAS 338751-61-4)
- Methyl 3-(4-chlorophenoxy)-4-nitrobenzoate (CAS 931414-11-8)
- Methyl 4-(4-chlorophenoxy)-3-nitrobenzoate (CAS 320416-58-8)
- (E)-[2-(4-Chlorophenoxy)-1-(4-chlorophenyl)ethylidene](methoxy)amine (CAS 320422-51-3)
Recommended Standards
- n-[(5-bromothiophen-2-yl)methyl]-2-chloro-n-(prop-2-en-1-yl)acetamide (CAS 923223-48-7)
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- 5-Chloro-3-(trifluoromethyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid (CAS 1152979-31-1)
- Abemaciclib Impurity 177 (CAS CATO-C4X-2937177)
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- 6-((4-Chlorobenzyl)thio)-9-propyl-9H-purin-2-amine (CAS 92494-54-7)
- 5-(Bromomethyl)benzene-1,3-diol (CAS 33617-40-2)
- tert-Butyl(1-(5-methyl-1H-imidazol-2-yl)ethyl)carbamate (CAS 887344-34-5)
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