2-(2-Chloro-4-methoxyphenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene CAS 2244084-86-2
| CAS No. | 2244084-86-2 |
| Molecular Formula | C14H8ClF5O2 |
| Molecular Weight | 338.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(2-Chloro-4-methoxyphenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene (C14H8ClF5O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-(2-Chloro-4-methoxyphenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene (CAS 2244084-86-2), a certified reference material (molecular formula C14H8ClF5O2, MW 338.66 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-(2-Chloro-4-methoxyphenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H8ClF5O2 |
| Molecular Weight | 338.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 4-Chloro-3-(difluoromethoxy)-4'-(trifluoromethoxy)-1,1'-biphenyl (CAS 1261507-48-5)
- 4'-Chloro-3'-(difluoromethoxy)-2-(trifluoromethoxy)-1,1'-biphenyl (CAS 1261583-53-2)
- 2-Chloro-4-(difluoromethoxy)-3'-(trifluoromethoxy)-1,1'-biphenyl (CAS 1261777-47-2)
- 4-Chloro-2-(difluoromethoxy)-2'-(trifluoromethoxy)-1,1'-biphenyl (CAS 1261777-55-2)
- 2-Chloro-4-(difluoromethoxy)-4'-(trifluoromethoxy)-1,1'-biphenyl (CAS 1261828-96-9)
- 2-Chloro-5-(difluoromethoxy)-2'-(trifluoromethoxy)-1,1'-biphenyl (CAS 1261837-33-5)
- 2-Chloro-3-(difluoromethoxy)-4'-(trifluoromethoxy)-1,1'-biphenyl (CAS 1261865-89-7)
- 2-(5-Chloro-2-methoxyphenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene (CAS 2244086-53-9)
Recommended Standards
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (4-(4-chlorophenyl)thiophen-2-yl)boronate (CAS 1402227-79-5)
- 1-(4-Bromothiophen-2-yl)-N-((5-chloro-1,2,3-thiadiazol-4-yl)methyl)-N-methylmethanamine (CAS 1248916-87-1)
- 4-((4-(Trifluoromethyl)pyrimidin-2-yl)oxy)benzenesulfonyl chloride (CAS 1160058-86-5)
- 4-{[2-(Trifluoromethyl)pyrimidin-4-yl]oxy}benzenesulfonyl chloride (CAS 1215542-63-4)
- tert-Butyl 4-Acetylbenzoate (CAS 105580-41-4)
- 2,3'-Dichloro-4'-fluorobenzophenone (CAS 951889-98-8)
- 1-(2-Bromo-3-fluorophenyl)propan-2-ol (CAS 1394042-02-4)
- (3,4-Dichloro-5-fluorophenyl)boronic acid (CAS 1023690-35-8)
- 5-(Pyridin-2-ylmethylene)-2-thioxo-3-(m-tolyl)thiazolidin-4-one (CAS 157325-78-5)
- 2-Chloro-N-(9-oxo-9H-thioxanthen-2-yl)benzamide (CAS 478248-52-1)
- Methyl furo[2,3-b]quinoline-4-carboxylate (CAS 37519-74-7)
- 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-indazole-6-carbonitrile (CAS 2377606-34-1)
- 5-Amino-N-ethyl-2-methyl-N-phenylbenzenesulfonamide (CAS 51123-09-2)
- Semaglutide impurity 61 (CAS CATO-C4X-222661)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com