1,3-Difluoro-2-(2-fluoro-4-nitrophenoxy)-5-(trifluoromethyl)benzene CAS 2244085-91-2
| CAS No. | 2244085-91-2 |
| Molecular Formula | C13H5F6NO3 |
| Molecular Weight | 337.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 1,3-Difluoro-2-(2-fluoro-4-nitrophenoxy)-5-(trifluoromethyl)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
1,3-Difluoro-2-(2-fluoro-4-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244085-91-2), molecular formula C13H5F6NO3 and molecular weight 337.17 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1,3-Difluoro-2-(2-fluoro-4-nitrophenoxy)-5-(trifluoromethyl)benzene (C13H5F6NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C13H5F6NO3 |
| Molecular Weight | 337.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 1,3-Difluoro-2-(2-fluoro-5-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244088-05-7)
- 1,3-Difluoro-2-(2-fluoro-6-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244087-46-3)
- 1,3-Difluoro-2-(3-fluoro-2-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244085-00-3)
- 1,3-Difluoro-2-(3-fluoro-4-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244083-25-6)
- 1,3-Difluoro-2-(4-fluoro-2-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244087-67-8)
- 1,3-Difluoro-2-(4-fluoro-3-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244087-40-7)
- 1,3-Difluoro-2-(5-fluoro-2-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244083-22-3)
- 4,4-Difluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine (CAS 1206594-03-7)
Recommended Standards
- (8-Oxa-3-azabicyclo[3.2.1]Octan-3-yl)(3-bromo-1H-pyrazolo[4,3-c]pyridin-6-yl)methanone (CAS 2416819-53-7)
- Ethyl 9-bromo-5,6-dihydrobenzo[f]pyrazolo[1,5-d][1,4]oxazepine-2-carboxylate (CAS 1956383-21-3)
- Methyl 4-(benzyloxy)-5-bromo-2-hydroxybenzoate (CAS 190278-38-7)
- 3-(4-Bromophenyl)-5H-indeno[1,2-c]pyridazin-5-one (CAS 166760-57-2)
- 3-(1,3-Benzodioxol-5-yl)acryloyl chloride (CAS 96249-87-5)
- 6-Isopropylpyrimidin-4-amine (CAS 1159818-06-0)
- 1-Benzyl-5-butyl-6-chloro-3-phenylpyridazin-4(1H)-one (CAS 919198-01-9)
- 2-(Chloromethyl)-6-(difluoromethyl)-3-methylpyridine-5-acetic acid (CAS 1361903-11-8)
- (R)-2-(3-Methoxyphenyl)propanoic acid (CAS 127641-45-6)
- N-(4-Aminophenyl)-3-methylbenzamide (CAS 425651-25-8)
- 1,5-Difluoro-6-methoxyisoquinoline (CAS 1409950-68-0)
- N-ethyl-2-(2-hydroxyacetyl)hydrazine-1-carbothioamide (CAS 1351398-83-8)
- 2-(3-Bromo-5-(methylsulfonyl)phenyl)propan-2-ol (CAS 1897390-95-2)
- Peptide 74 (H-8545.0500) (CAS 132116-39-3)
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