5-Bromo-8-(difluoromethyl)quinoline CAS 2248394-00-3
| CAS No. | 2248394-00-3 |
| Molecular Formula | C10H6BrF2N |
| Molecular Weight | 258.06 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Bromo-8-(difluoromethyl)quinoline (CAS 2248394-00-3), molecular formula C10H6BrF2N and molecular weight 258.06 g/mol, is a CATO reference standard with documented purity and traceability.
5-Bromo-8-(difluoromethyl)quinoline (C10H6BrF2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6BrF2N |
| Molecular Weight | 258.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 4-Bromo-5,7-difluoro-2-methylquinoline (CAS 1189105-77-8)
- 4-Bromo-5,8-difluoro-2-methylquinoline (CAS 1189105-80-3)
- 4-Bromo-7,8-difluoro-2-methylquinoline (CAS 1189106-60-2)
- 2-Bromo-6-((trifluoromethyl)thio)pyridine (CAS 1204234-28-5)
- 5-bromo-2-[(trifluoromethyl)sulfanyl]pyridine (CAS 1204234-35-4)
- 3-Bromo-5-((trifluoromethyl)thio)pyridine (CAS 1204234-43-4)
- 4-Bromo-2-((trifluoromethyl)thio)pyridine (CAS 1204234-49-0)
- 2-Bromo-5-(trifluoromethylthio)pyridine (CAS 1204234-94-5)
Recommended Standards
- 5-Bromo-1-(difluoromethyl)isoquinoline (CAS 2169656-77-1)
- 5-Iodo-1-methyl-1H-benzo[d]imidazole (CAS 705262-59-5)
- 5,8-Dichloro-4-hydroxyquinoline-3-carboxylic acid (CAS 35973-26-3)
- 5-Iodo-2,3-dihydro-1H-inden-1-one (CAS 511533-38-3)
- 5-(3H-imidazo[4,5-c]pyridin-2-yl)quinoline (CAS 1356783-28-2)
- 2-(2-(Trifluoromethyl)phenyl)pyridin-3-amine (CAS 886507-97-7)
- (1R)-1-(4-methyl-1,3-thiazol-5-yl)ethan-1-amine hydrochloride (CAS 1864002-96-9)
- 4-Methylthiazole-5-sulfonic acid (CAS 114389-49-0)
- (R)-2-((1-(tert-Butoxycarbonyl)pyrrolidin-3-yl)(cyclopropyl)amino)acetic acid (CAS 1354002-16-6)
- 2,3-Dichloro-N-[2-(2,6-dimethylphenoxy)propyl]-aniline (CAS 1040682-35-6)
- 3-(3,5-dimethyl-1H-pyrazol-1-yl)-1$l^{6}-thiolane-1,1-dione (CAS 17115-84-3)
- 1-(2,4-Dichlorophenyl)ethanol (CAS 1475-13-4)
- 2-(Difluoromethyl)-5-fluoropyridin-4-amine (CAS 1806762-07-1)
- Liraglutide(5-31)TFA Salt (CAS CATO-C4X-19924)
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