Sitagliptin Impurity 81 CAS 2248445-08-9
| CAS No. | 2248445-08-9 |
| Molecular Formula | C14H17F3N2O2 |
| Molecular Weight | 302.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Sitagliptin Impurity 81 (CAS 2248445-08-9) is a certified pharmaceutical impurity reference standard with the molecular formula C14H17F3N2O2 and a molecular weight of 302.29 g/mol.
The molecular framework of Sitagliptin Impurity 81 (C14H17F3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Sitagliptin Impurity 81 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H17F3N2O2 |
| Molecular Weight | 302.29 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Sitagliptin Standards
- Sitagliptin Impurity 134 (CAS CATO-C4X-1144134)
- Sitagliptin Impurity 160 (CAS CATO-C4X-1144160)
- Sitagliptin Impurity 82 (CAS 2248445-00-1)
- Sitagliptin Impurity 135 (CAS 1360872-54-3)
- Sitagliptin Impurity 70 (CAS CATO-C4X-114470)
- Sitagliptin Impurity 71 (CAS CATO-C4X-114471)
- Sitagliptin Impurity 26 (CAS 218609-00-8)
- Sitagliptin related compound 1 (CAS 331763-66-7)
Recommended Standards
- Ruxolitinib Impurity 236 (CAS CATO-C4X-2058236)
- Tert-butyl 5-(trifluoromethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate (CAS 2366994-11-6)
- Baricitinib Impurity 122 (CAS CATO-C4X-2260122)
- tert-Butyl 3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (CAS 624734-26-5)
- Allisartan Isoproxil Impurity 12 (CAS CATO-C4X-321712)
- Esmolol Impurity 53 (CAS 5535-03-5)
- Sodium Cromoglicate Impurity 15 (CAS 149992-30-3)
- 1-(Chloroacetyl)-4-phenylpiperidine (CAS 87358-96-1)
- 3-Phenyl-5-(pyrrolidin-3-yl)-1,2,4-oxadiazole (CAS 1480077-98-2)
- Hexanal 2,4-Dinitrophenylhydrazone (CAS 1527-97-5)
- CRT0044876 (CAS 6960-45-8)
- L-(-)-Fucose (CAS 2438-80-4)
- 2-((3-(2-Chlorophenyl)-1,2,4-thiadiazol-5-yl)thio)-N-(o-tolyl)acetamide (CAS 864919-05-1)
- [D-Glu]3-Semaglutide (CAS CATO-C4X-2226253)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com