4-Acetoxy-4'-fluoro-[1,1'-biphenyl]-3-carboxylic acid CAS 22494-27-5
| CAS No. | 22494-27-5 |
| Molecular Formula | C15H11FO4 |
| Molecular Weight | 274.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Acetoxy-4'-fluoro-[1,1'-biphenyl]-3-carboxylic acid.
4-Acetoxy-4'-fluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 22494-27-5), molecular formula C15H11FO4 and molecular weight 274.24 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Acetoxy-4'-fluoro-[1,1'-biphenyl]-3-carboxylic acid (C15H11FO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H11FO4 |
| Molecular Weight | 274.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
Related Acetoxy Standards
- 4-AcetoxyÂbutyric anhydride (CAS 150620-32-9)
- 4-Acetoxy-N-isopropyl-N-methyltryptamine (CAS 1024612-25-6)
- 103060-18-0 4-Acetoxy-4'-chlorobenzophenone 7732AC C15H11ClO3 (CAS 103060-18-0)
- 2-Acetoxy-4-chlorobenzophenone (CAS 890099-13-5)
- 3-Acetoxy-4-chlorobenzophenone (CAS 890099-55-5)
- N-Acetoxy-2-((2-methylquinolin-8-yl)oxy)acetimidamide (CAS 88757-97-5)
- 4-Acetoxy-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (CAS 1210863-93-6)
- Methyl 4-acetoxy-3-bromobenzoate (CAS 149817-68-5)
Recommended Standards
- 4-(4-Fluorophenyl)-6-(trifluoromethyl)pyrimidine-2-thiol (CAS 359899-79-9)
- 4-Formyl-2-methoxyphenyl 2-fluorobenzoate (CAS 380193-74-8)
- 4-(4-(Trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-carboxylic acid (CAS 473706-07-9)
- 4-Formyl-2-methoxyphenyl 3-fluorobenzoate (CAS 329715-03-9)
- N1-Methyl-N1-(1-(thiazol-2-yl)ethyl)ethane-1,2-diamine (CAS 1353943-83-5)
- Methyl 4-aminocyclopent-2-ene-1-carboxylate hydrochloride (CAS 1169936-02-0)
- (6-Morpholinopyridin-2-yl)methanol (CAS 432554-77-3)
- 4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenylboronic acid (CAS 1191062-02-8)
- (2-Bromo-3-fluorophenyl)methanesulfonamide (CAS 1499382-63-6)
- N-Methyl-3-(piperidin-4-yl)-1H-1,2,4-triazole-5-carboxamide hydrochloride (CAS 2126162-46-5)
- 7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-amine (CAS 698985-54-5)
- 2-(Tetrahydrofuran-3-yl)ethanethioamide (CAS 1247595-06-7)
- 3-chlorobicyclo[1.1.1]pentane-1-carboxylic acid (CAS 156329-73-6)
- Semaglutide impurity 107 (CAS CATO-C4X-2226107)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com