4-(4-(Trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-carboxylic acid CAS 473706-07-9
| CAS No. | 473706-07-9 |
| Molecular Formula | C13H13F3O3 |
| Molecular Weight | 274.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-(4-(Trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-carboxylic acid (CAS 473706-07-9) is a high-purity analytical reference standard with the molecular formula C13H13F3O3 and a molecular weight of 274.24 g/mol.
Based on its molecular formula C13H13F3O3, 4-(4-(Trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-carboxylic acid contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 274.24 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H13F3O3 |
| Molecular Weight | 274.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Trifluoromethyl Standards
- 6-(4-(Trifluoromethyl)piperidin-1-yl)nicotinic acid (CAS 1033463-36-3)
- 4-(3-(Trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-carboxylic acid (CAS 1035261-84-7)
- 2-(4-(Trifluoromethyl)phenyl)quinazoline (CAS 1208259-10-2)
- 1-[4-(Trifluoromethyl)-2-pyridyl]piperidine-4-carboxylic Acid (CAS 1256792-04-7)
- 3-{[4-(trifluoromethyl)phenyl]methyl}oxolane-3-carboxylic acid (CAS 1281657-95-1)
- 4-[2-(Trifluoromethyl)phenyl]oxane-4-carboxylic acid (CAS 1385696-72-9)
- Methyl 5-(4-(trifluoromethyl)phenyl)tetrahydrofuran-2-carboxylate (CAS 1421601-10-6)
- Methyl 5-(2-(trifluoromethyl)phenyl)tetrahydrofuran-2-carboxylate (CAS 1421602-29-0)
Recommended Standards
- 3-Piperidin-1-yl-5-(trifluoromethyl)-pyridine-2-carboxylic acid (CAS 1993196-70-5)
- 4-(4-Fluorophenyl)-6-(trifluoromethyl)pyrimidine-2-thiol (CAS 359899-79-9)
- 3-(3-Fluorophenyl)-3-hydroxy-5-methoxyisobenzofuran-1(3H)-one (CAS 919475-62-0)
- 4-Acetoxy-4'-fluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 22494-27-5)
- 3,3'-Azanediyldiphen (CAS 65461-91-8)
- (4-Methoxybenzyl)(triphenyl)phosphonium bromide (CAS 1530-38-7)
- Tetrakis(octadecylthio) Tetrathiafulvalene (CAS 105782-53-4)
- 6-Chlorofuro[3,4-c]pyridin-3(1H)-one, >97% (CAS 1352893-24-3)
- 5-(1-Isopropylpiperidin-2-yl)-1H-indole (CAS 1355201-31-8)
- Finerenone Impurity 286 (CAS CATO-C4X-2880286)
- 1-(4-Fluorophenyl)cyclopropanecarbaldehyde (CAS 155598-00-8)
- 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-5-[(1E)-1-[2-(4-chlorophenyl)hydrazin-1-ylidene]ethyl]-3-[(4-fluorophenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 338410-11-0)
- Tofacitinib Related Compound 99 HCl (CAS 1629858-78-1 (free base))
- Semaglutide impurity 40 (CAS CATO-C4X-222640)
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