Crisaborole impurity 131 CAS 2250222-38-7
| CAS No. | 2250222-38-7 |
| Molecular Formula | C20H22BNO4 |
| Molecular Weight | 351.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Crisaborole impurity 131 (CAS 2250222-38-7, C20H22BNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H22BNO4, Crisaborole impurity 131 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 351.20 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Crisaborole impurity 131 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H22BNO4 |
| Molecular Weight | 351.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 61 (CAS CATO-C4X-202161)
- Crisaborole Impurity 37 (CAS CATO-C4X-202137)
- Crisaborole Impurity 26 (CAS CATO-C4X-202126)
- Crisaborole Impurity 27 (CAS 2141947-89-7)
- Crisaborole impurity 129 (CAS CATO-C4X-2021129)
- Crisaborole lmpurity 100 (CAS CATO-C4X-2021100)
- Crisaborole lmpurity 101 (CAS CATO-C4X-2021101)
- Crisaborole impurity 105 (CAS CATO-C4X-2021105)
Recommended Standards
- Methyl 4-(((4-bromo-5-(dimethylamino)furan-2-yl)methylene)amino)benzoate (CAS 469895-89-4)
- 1-(3-Bromo-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-4-amine (CAS 1707605-13-7)
- Methyl 2-(3-(4-bromophenyl)-6-oxopyridazin-1(6H)-yl)butanoate (CAS 853333-96-7)
- 1-(2-Bromo-6-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-4-amine (CAS 1713160-28-1)
- Clevidipine butyrate Impurity 25 (CAS 43107-08-0)
- Opicapone impurity 26 (CAS CATO-C4X-240426)
- Granisetron EP Impurity F (CAS 1364914-39-5(free base))
- {imidazo[1,2-a]pyridin-2-ylmethyl}(methyl)amine (CAS 193534-56-4)
- 3-(2-((tert-Butoxycarbonyl)amino)-2-iminoethyl)benzoic acid (CAS 891782-64-2)
- 1-(3-(P-tolyl)benzo[c]isoxazol-5-yl)ethan-1-one (CAS 439094-63-0)
- 2,6-Dichloro-3-hydroxybenzonitrile (CAS 3336-34-3)
- 2-(Aminomethyl)-5-(difluoromethyl)-3-iodopyridine-6-carboxylic acid (CAS 1805264-86-1)
- n-Allyl-n-(2,2,2-trifluoroacetyl)glycine (CAS 1501030-03-0)
- (Des-His1,Glu?)-Glucagon (1-29) amide (human, rat, porcine) (CAS 110084-95-2)
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