Crisaborole lmpurity 100 CAS CATO-C4X-2021100
| CAS No. | CATO-C4X-2021100 |
| Molecular Formula | C16H12BrNO3 |
| Molecular Weight | 346.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Crisaborole lmpurity 100 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Crisaborole lmpurity 100 (CAS CATO-C4X-2021100), a pharmacopoeial impurity reference standard (molecular formula C16H12BrNO3, MW 346.18 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Crisaborole lmpurity 100 (C16H12BrNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H12BrNO3 |
| Molecular Weight | 346.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole lmpurity 101 (CAS CATO-C4X-2021101)
- Crisaborole impurity 105 (CAS CATO-C4X-2021105)
- Crisaborole impurity 108 (CAS CATO-C4X-2021108)
- Crisaborole impurity 113 (CAS CATO-C4X-2021113)
- Crisaborole impurity 156 (CAS CATO-C4X-2021156)
- Crisaborole Impurity 65 (CAS 1217366-74-9)
- Crisaborole lmpurity 76 (CAS 2227126-09-0)
- Crisaborole impurity 129 (CAS CATO-C4X-2021129)
Recommended Standards
- Enrofloxacin Impurity 10 (CAS CATO-C4X-162810)
- 2-[(E)-2-(2-bromophenyl)hydrazono]-3-(3,5-dimethyl-1H-pyrazol-1-yl)-3-oxopropanenitrile 477710-17-1 KS-00001TV3 (CAS 477710-17-1)
- Ethyl 3-(5-(2-bromophenyl)furan-2-yl)-2-cyanoacrylate (CAS 853347-59-8)
- Ethyl (E)-3-(5-(4-bromophenyl)furan-2-yl)-2-cyanoacrylate (CAS 299953-97-2)
- Bosentan impurity 17 (CAS CATO-C4X-156417)
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- 1-((2R,4S,5R)-4-(Allyloxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (CAS 211191-57-0)
- N-(3-chloro-4-fluorophenyl)-2-(4-(2-fluorophenyl)piperazin-1-yl)acetamide (CAS 329080-46-8)
- Voriconazole Impurity 27 (CAS 1702684-04-5)
- 4-Methyl-N-(7-methyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]oxazepin-2-yl)benzenesulfonamide (CAS 866152-15-0)
- N,N-Dimethylbenzo[d]isothiazol-3-amine (CAS 22801-55-4)
- Semaglutide impurity 229 (CAS CATO-C4X-2226229)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com