Valsartan Impurity 67 CAS 2254485-68-0
| CAS No. | 2254485-68-0 |
| Molecular Formula | C19H20N6O3 |
| Molecular Weight | 380.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Valsartan Impurity 67 (CAS 2254485-68-0, C19H20N6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C19H20N6O3, Valsartan Impurity 67 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 380.40 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H20N6O3 |
| Molecular Weight | 380.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 6 |
Related Valsartan Standards
- Valsartan Impurity 135 (CAS CATO-C4X-1057135)
- Valsartan impurity 19 (CAS CATO-C4X-105719)
- Valsartan Impurity 110 (CAS 1418314-03-0)
- Valsartan Impurity 105 (CAS CATO-C4X-1057105)
- Valsartan Impurity 48 (CAS 1314799-74-0)
- Valsartan Impurity 126 (CAS CATO-C4X-1057126)
- Valsartan Impurity 42 (CAS 443093-86-5)
- Valsartan Impurity 111 (CAS CATO-C4X-1057111)
Recommended Standards
- N-nitroso(tetrazole) Valsartan Desvaleryl Impurity 87 (CAS CATO-C4X-105787)
- tert-butyl N-(tert-butoxycarbonylamino)-N-[3-(2,2,2-trifluoroethyl)-1-bicyclo[1.1.1]pentanyl]carbamate (CAS 2149634-68-2)
- Rivaroxaban Impurity 124 (CAS CATO-C4X-1090124)
- RDEA-427 (CAS 914496-19-8)
- Mosapride Impurity 61 (CAS CATO-C4X-104461)
- Finasteride Impurity 14 (CAS 302-97-6)
- Methotrexate Impurity 78 (CAS CATO-C4X-115478)
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- 2-(2-(Methylimino)-4-phenyl-2,3-dihydrothiazol-5-yl)acetic acid (CAS 878081-71-1)
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- 1-(2-Nitrophenoxy)propan-2-one (CAS 5330-66-5)
- Neuroendocrine Regulatory Peptide-1 (rat) (CAS 954420-51-0)
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