3,5-Dichloro-2-methoxybenzoic acid CAS 22775-37-7
| CAS No. | 22775-37-7 |
| Molecular Formula | C8H6Cl2O3 |
| Molecular Weight | 221.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 221.04 g/mol gives 3,5-Dichloro-2-methoxybenzoic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 3,5-Dichloro-2-methoxybenzoic acid (CAS 22775-37-7), a certified reference material (molecular formula C8H6Cl2O3, MW 221.04 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 3,5-Dichloro-2-methoxybenzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 221.04 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6Cl2O3 |
| Molecular Weight | 221.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
Related Dichloro Standards
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- 2,4-Dichloro-3-methoxybenzoic acid (CAS 115382-33-7)
- Methyl 2,4-dichloro-3-hydroxybenzoate (CAS 129788-30-3)
- 4,5-Dichloro-2-(2-oxopropyl)pyridazin-3(2H)-one (CAS 130159-58-9)
- Methyl 2,6-dichloro-3-hydroxybenzoate (CAS 142601-42-1)
- 3,4-Dichloro-2-methoxybenzoic acid (CAS 155382-86-8)
- (3,4-Dichloro-2-nitrophenyl)methanamine (CAS 1804897-45-7)
- Methyl 2,4-dichloro-5-hydroxybenzoate (CAS 1806282-22-3)
Recommended Standards
- 2 - Bromomethyl - 1,3 - difluoro - 4 - methyl - benzene 2,6-Difluoro-3-methylbenzyl bromide 2-(bromomethyl)-1,3-difluoro-4-methylbenzene 261763-44-4 benzene, 2-(bromomethyl)-1,3-difluoro-4-methyl- (CAS 261763-44-4)
- Norepinephrine Impurity 55 (CAS CATO-C4X-151455)
- Methyl 4,5-dichloro-2-hydroxybenzoate (CAS 63483-07-8)
- Anagrelide Impurity 1 (CAS 70380-49-3)
- 4-Iodobutyl Tetrahydropyranyl Ether (CAS 41049-30-3)
- tert-Butyl 3-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)piperazine-1-carboxylate (CAS 1677705-58-6)
- 1-(4-methylpyridin-2-yl)-5-propyl-1H-pyrazol-4-amine hydrochloride (CAS 1461704-83-5)
- Rel-(+)-(1r,2s,3r,4s)-3-{[(tert-butoxy)carbonyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid (CAS 1821718-77-7)
- Bicalutamide Impurity 32 (CAS CATO-C4X-101332)
- methyl 5-sulfamoylpyridine-3-carboxylate (CAS 1315368-60-5)
- 1-(2-(Decyloxy)-2-oxoethyl)-1-heptylazepan-1-ium hydroxide (CAS 76391-82-7)
- 2-[4-(Methylsulfonyl)phenyl]-4-pentyn-2-ol (CAS 2006278-32-4)
- 1-(tert-Butoxycarbonyl)-3-(4-methylphenyl)-2-pyrrolidinecarboxylic acid (CAS 1822493-31-1)
- Tirzepatide Impurity 46 (CAS CATO-C4X-324046)
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