Ethyl 2-hydroxy-5-methoxybenzoate CAS 22775-40-2
| CAS No. | 22775-40-2 |
| Molecular Formula | C10H12O4 |
| Molecular Weight | 196.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 2-hydroxy-5-methoxybenzoate (CAS 22775-40-2), molecular formula C10H12O4 and molecular weight 196.20 g/mol, is a CATO reference standard with documented purity and traceability.
Ethyl 2-hydroxy-5-methoxybenzoate (C10H12O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12O4 |
| Molecular Weight | 196.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
Related Ethyl Standards
- 5-Ethyl-2-hydroxy-3-methoxybenzoic acid (CAS 100245-34-9)
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- 5-Hydroxy-2-(2-tetrahydropyranyl)pyridazin-3(2H)-one (CAS 1008517-74-5)
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Recommended Standards
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- 8-Fluoro-3-iodo-6-methylquinoline (CAS 1592298-19-5)
- 17a(H),21B(H)-30-Norhopane (CAS 53584-60-4)
- 5-[(4-Methylphenyl)sulfanyl]-1,3-diphenyl-1H-pyrazole-4-carbaldehyde (CAS 956744-37-9)
- 3-(4-Methoxyphenyl)-1-(piperidin-4-yl)urea hydrochloride (CAS 1233955-68-4)
- 2-azatricyclo[7.3.0.0³⁷]dodeca-1,3(7),8-trien-8-amine (CAS 62732-43-8)
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