Lifitegrast Impurity 35 CAS 2295862-29-0
| CAS No. | 2295862-29-0 |
| Molecular Formula | C30H26Cl2N2O7S |
| Molecular Weight | 629.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Lifitegrast Impurity 35 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 629.51 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Lifitegrast Impurity 35 (CAS 2295862-29-0, C30H26Cl2N2O7S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H26Cl2N2O7S |
| Molecular Weight | 629.51 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 122 (CAS CATO-C4X-2409122)
- Lifitegrast Impurity 34 (CAS CATO-C4X-240934)
- Lifitegrast Impurity 59 (CAS CATO-C4X-240959)
- Lifitegrast Impurity 83 (CAS CATO-C4X-240983)
- Lifitegrast Impurity 121 (CAS CATO-C4X-2409121)
- Lifitegrast Impurity 58 (CAS CATO-C4X-240958)
- Lifitegrast Impurity 7 (CAS CATO-C4X-24097)
- Lifitegrast Impurity 82 (CAS CATO-C4X-240982)
Recommended Standards
- (Bis((4-chlorophenyl)thio)methylene)bis((diisopropyl-l3-oxidanyl)phosphinic acid) (CAS 887353-24-4)
- Platinum,phenyl(η3-2-propenyl)[tris(4-fluorophenyl)phosphine]- (CAS 115603-59-3)
- N-[2-[[6-[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methylureido]-4-pyrimidinyl]amino]-5-(4-ethyl-1-piperazinyl)phenyl]acrylamide (CAS 1702259-66-2)
- Pigment Yellow 13 (CAS 6358-85-6)
- Osimertinib Impurity 7 (CAS 2919324-18-6)
- Beclometasone Dipropionate Monohydrate EP Impurity E (CAS 887130-68-9)
- Fluralaner Impurity 17 (CAS CATO-C4X-218017)
- (S)-3-(4-Fluorophenoxy)pyrrolidine (CAS 1187927-92-9)
- Orthosporin (CAS 118063-79-9)
- 6-[(1S)-1-Aminoethyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS 1187932-02-0)
- 1-(4-(Cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)ethanol (CAS 362656-31-3)
- 3-Bromo-6-iodopyrazine-2-carbonitrile (CAS 1823919-86-3)
- 4-Methyl-N'-(4-methyl-1,2,3-thiadiazole-5-carbonyl)benzenesulfonohydrazide (CAS 477872-09-6)
- Liraglutide(10-22)TFA Salt (CAS CATO-C4X-199211)
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