Lifitegrast Impurity 83 CAS CATO-C4X-240983
| CAS No. | CATO-C4X-240983 |
| Molecular Formula | C29H22Cl2N2O8S |
| Molecular Weight | 629.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Lifitegrast Impurity 83 (CAS CATO-C4X-240983, C29H22Cl2N2O8S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Lifitegrast Impurity 83 (C29H22Cl2N2O8S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 19.0, corresponding to approximately 19 ring(s) or double-bond equivalent(s). With a molecular weight of 629.46 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C29H22Cl2N2O8S |
| Molecular Weight | 629.46 g/mol |
| Purity | ＞95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 34 (CAS CATO-C4X-240934)
- Lifitegrast Impurity 59 (CAS CATO-C4X-240959)
- Lifitegrast Impurity 122 (CAS CATO-C4X-2409122)
- Lifitegrast Impurity 35 (CAS 2295862-29-0)
- Lifitegrast Impurity 38 (CAS CATO-C4X-240938)
- Lifitegrast Impurity 57 (CAS CATO-C4X-240957)
- Lifitegrast Impurity 121 (CAS CATO-C4X-2409121)
- Lifitegrast Impurity 58 (CAS CATO-C4X-240958)
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