(1R)-7-Chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione CAS 2300966-23-6
| CAS No. | 2300966-23-6 |
| Molecular Formula | C16H14ClFN4O2 |
| Molecular Weight | 348.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies (1R)-7-Chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (CAS 2300966-23-6), a certified reference material (molecular formula C16H14ClFN4O2, MW 348.76 g/mol) for analytical method development and quality control.
The molecular framework of (1R)-7-Chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (C16H14ClFN4O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H14ClFN4O2 |
| Molecular Weight | 348.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related R Standards
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- 1-(4-Chloro-3-nitrobenzenesulfonyl)piperidine-4-carboxylic acid (CAS 368427-83-2)
- 7-Chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (CAS 2252403-82-8)
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Recommended Standards
- Benzo[d]oxazol-2-yl(2-chloro-6-fluorophenyl)methyl dimethylcarbamate (CAS 104029-82-5)
- Benzo[d]oxazol-2-yl(2-chloro-6-fluorophenyl)methyl ethylcarbamate (CAS 104029-78-9)
- 7-(4-Chlorophenyl)-2-(2-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (CAS 860611-28-5)
- 4-Chlorophenyl (3Z)-3-{[(4-nitrophenyl)methoxy]imino}propanoate (CAS 338395-26-9)
- L-3,6-Bis(ß-chloroethyl)-2,5-diketopiperazine (CAS 1333325-25-9)
- Urobilin Hydrochloride (CAS 28925-89-5)
- 2-((3-(Trifluoromethyl)phenyl)amino)quinazolin-4(3H)-one (CAS 477887-09-5)
- Biapenem Impurity 21 (CAS 153851-71-9)
- 5-Chloro-2-[(3,4,4-trifluoro-3-butenyl)sulfinyl]thiazole (CAS 318290-97-0)
- Pcb No. 178 (CAS 52663-67-9)
- 2-Bromo-1-(2-chloro-3-nitrophenyl)ethanone (CAS 1160098-73-6)
- 5-(Aminomethyl)-6-methylpyrimidine-2,4-diol (CAS 858001-23-7)
- 2-Chloro-3-hydroxypyridine 1-oxide (CAS 30810-20-9)
- Semaglutide Impurity 123 (CAS 71997-93-8)
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