1-(tert-Butyl) 2-methyl (2R,4R)-4-(difluoromethyl)pyrrolidine-1,2-dicarboxylate CAS 2301881-89-8

Purity 97%+In StockPharmaceutical Standards
CAS No.2301881-89-8
Molecular FormulaC12H19F2NO4
Molecular Weight279.28 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

1-(tert-Butyl) 2-methyl (2R,4R)-4-(difluoromethyl)pyrrolidine-1,2-dicarboxylate CAS 2301881-89-8 chemical structure

Description

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

CATO supplies 1-(tert-Butyl) 2-methyl (2R,4R)-4-(difluoromethyl)pyrrolidine-1,2-dicarboxylate (CAS 2301881-89-8), a certified reference material (molecular formula C12H19F2NO4, MW 279.28 g/mol) for analytical method development and quality control.

The molecular framework of 1-(tert-Butyl) 2-methyl (2R,4R)-4-(difluoromethyl)pyrrolidine-1,2-dicarboxylate (C12H19F2NO4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

As a certified reference material (CRM), 1-(tert-Butyl) 2-methyl (2R,4R)-4-(difluoromethyl)pyrrolidine-1,2-dicarboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC12H19F2NO4
Molecular Weight279.28 g/mol
AppearanceWhite to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)3.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1999
Halogen ContentF-containing
Nitrogen Atoms1

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