8,8-Difluoro-5-oxa-2-azaspiro[3.4]Octane CAS 2306270-84-6
| CAS No. | 2306270-84-6 |
| Molecular Formula | C6H9F2NO |
| Molecular Weight | 149.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 8,8-Difluoro-5-oxa-2-azaspiro[3.4]Octane.
8,8-Difluoro-5-oxa-2-azaspiro[3.4]Octane (CAS 2306270-84-6), molecular formula C6H9F2NO and molecular weight 149.14 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 8,8-Difluoro-5-oxa-2-azaspiro[3.4]Octane is typically white to off-white liquid. Its solid-state physicochemical attributes — including a molecular weight of 149.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H9F2NO |
| Molecular Weight | 149.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 2,2-Difluoro-1-pyrrolidin-1-yl-ethanone (CAS 109872-83-5)
- 7,7-Difluoro-5-oxa-2-azaspiro[3.4]octane (CAS 1214875-26-9)
- 3,3-Difluoro-1-(oxetan-3-yl)azetidine (CAS 1823325-13-8)
- 3,3-Difluoro-6-methylpiperidin-2-one (CAS 2138510-27-5)
- 3,4-Difluoro-1-Methyl-2,5-Pyrrolidinedione (CAS 56154-78-0)
- 4,4-difluoro-3,3-dimethylpiperidine (CAS 1198392-56-1)
- 4,4-Difluoro-1-methylcyclohexan-1-amine (CAS 1389442-00-5)
- 4,4-Difluoro-3,5-dimethylpiperidine (CAS 1783745-21-0)
Recommended Standards
- 5,5-Difluoroazepan-2-one (CAS 35196-96-4)
- N-(4,4-difluorocyclohexylidene)hydroxylamine (CAS 2021983-28-6)
- 3,5-difluoropyridine-4-carbaldehyde (CAS 870234-98-3)
- 53931-70-7 dl-glutamic acid-3,3-d2 (CAS 53931-70-7)
- DMG-PEG 2000 (CAS 1397695-86-1)
- 2-((4-Allyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(benzo[d][1,3]dioxol-5-yl)acetamide (CAS 586994-47-0)
- 1-(Cyclopentyloxy)-3-fluoro-2-nitrobenzene (CAS 1233952-84-5)
- 2-(2,4-Dimethoxyphenyl)acetonitrile (CAS 1891-11-8)
- 2-((Tert-butylamino)methyl)-4-methylphenol (CAS 136029-04-4)
- (R)-1-(3,5-dimethoxyphenyl)propan-1-amine hydrochloride (CAS 2061996-46-9)
- 1-(4-Acetyl-3,5-dimethyl-2-pyrrolyl)-2-chloroethanone (CAS 750611-31-5)
- 2-Bromo-4-nitrobenzene-1-sulfonyl chloride (CAS 1099660-60-2)
- n-((1,2,3-Thiadiazol-4-yl)methyl)-1-(1-ethylpyrrolidin-2-yl)methanamine (CAS 1157056-22-8)
- MCH-Gene-Overprinted-Polypeptide-14 (rat) (H-4746.0500) (CAS 182917-44-8)
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