6-Fluorobenzo[c]isoxazole-3-carbonitrile CAS 23073-23-6
| CAS No. | 23073-23-6 |
| Molecular Formula | C8H3FN2O |
| Molecular Weight | 162.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-Fluorobenzo[c]isoxazole-3-carbonitrile (CAS 23073-23-6), molecular formula C8H3FN2O and molecular weight 162.12 g/mol, is a CATO reference standard with documented purity and traceability.
6-Fluorobenzo[c]isoxazole-3-carbonitrile (C8H3FN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Fluorobenzo[c]isoxazole-3-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H3FN2O |
| Molecular Weight | 162.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluorobenzo Standards
- 4-Fluorobenzo[d]oxazole-2-carbonitrile (CAS 1172606-57-3)
- 6-Fluorobenzo[d]isoxazole-3-carbonitrile (CAS 1314937-26-2)
- 5-Fluorobenzo[c]isoxazole-3-carbonitrile (CAS 194873-12-6)
- 6-Fluorobenzo[e][1,2,4]triazin-3-amine (CAS 680180-41-0)
- 7-Fluorobenzo[e][1,2,4]triazin-3-amine (CAS 74916-44-2)
- 6-Fluorobenzo[d][1,2,3]triazin-4(1H)-one (CAS 1008742-31-1)
- 7-Fluorobenzo[d][1,2,3]triazin-4(1H)-one (CAS 1436850-60-0)
- 6-Fluorobenzo[d]isoxazole-3-carbaldehyde (CAS 1824114-20-6)
Recommended Standards
- 5-fluoro-2-isocyanatobenzonitrile (CAS 923232-26-2)
- Diethyl ethynylphosphonate (CAS 4851-51-8)
- 4-fluoro-2-isocyanatobenzonitrile (CAS 923255-70-3)
- Trimethylolpropane Phosphite (CAS 824-11-3)
- 1-(3-Ethyl-1h-1,2,4-triazol-5-yl)ethan-1-ol (CAS 1248299-89-9)
- METHYL 4-(TERT-BUTOXYCARBONYL(METHYL)AMINO)BENZOATE (CAS 741275-29-6)
- 3,4-Bis(difluoromethoxy)aniline (CAS 71791-36-1)
- 3-((2-Fluorobenzyl)thio)-5-(furan-2-yl)-4-methyl-4H-1,2,4-triazole (CAS 498551-14-7)
- 1-Amino-1H-1,2,4-triazole-3-carboxylic acid (CAS 142415-65-4)
- Methyl 3-Amino-4-phenylbutanoate (CAS 129042-93-9)
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